Endocytosis of Membrane Receptors: Two Pathways Are Better Than One

Aguilar and Wendland discuss two studies that show how Ub can act as an endocytic signal in mammalian cells; in the absence of clathrin, Ub can direct entry via a CIE pathway. It appears that endocytic factors may play multiple roles, depending on which signal the cargo protein presents, or which en...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2005-02, Vol.102 (8), p.2679-2680
Main Authors: Aguilar, Rubén Claudio, Wendland, Beverly
Format: Article
Language:English
Subjects:
Cell membranes
Clathrin - physiology
Commentaries
Endocytosis
Eukaryotes
Freight
Humans
Internalization
Ligands
Membranes
Physiological regulation
Proteins
Rafts
Receptors
Receptors, Cell Surface - metabolism
Signal transduction
Ubiquitin - metabolism
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Summary:Aguilar and Wendland discuss two studies that show how Ub can act as an endocytic signal in mammalian cells; in the absence of clathrin, Ub can direct entry via a CIE pathway. It appears that endocytic factors may play multiple roles, depending on which signal the cargo protein presents, or which endocytic route is being used.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.0500213102