Endocytosis of Membrane Receptors: Two Pathways Are Better Than One

Aguilar and Wendland discuss two studies that show how Ub can act as an endocytic signal in mammalian cells; in the absence of clathrin, Ub can direct entry via a CIE pathway. It appears that endocytic factors may play multiple roles, depending on which signal the cargo protein presents, or which en...

Full description

Saved in:
Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2005-02, Vol.102 (8), p.2679-2680
Main Authors: Aguilar, Rubén Claudio, Wendland, Beverly
Format: Article
Language:English
Subjects:
Cell membranes
Clathrin - physiology
Commentaries
Endocytosis
Eukaryotes
Freight
Humans
Internalization
Ligands
Membranes
Physiological regulation
Proteins
Rafts
Receptors
Receptors, Cell Surface - metabolism
Signal transduction
Ubiquitin - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c559t-d522a1a4482612f3cb663178d287b6f97cd35906bef6d5bab7b9fa6c2379b56c3
cites cdi_FETCH-LOGICAL-c559t-d522a1a4482612f3cb663178d287b6f97cd35906bef6d5bab7b9fa6c2379b56c3
container_end_page 2680
container_issue 8
container_start_page 2679
container_title Proceedings of the National Academy of Sciences - PNAS
container_volume 102
creator Aguilar, Rubén Claudio
Wendland, Beverly
description Aguilar and Wendland discuss two studies that show how Ub can act as an endocytic signal in mammalian cells; in the absence of clathrin, Ub can direct entry via a CIE pathway. It appears that endocytic factors may play multiple roles, depending on which signal the cargo protein presents, or which endocytic route is being used.
doi_str_mv 10.1073/pnas.0500213102
format article
fullrecord <record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_549498</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>3374679</jstor_id><sourcerecordid>3374679</sourcerecordid><originalsourceid>FETCH-LOGICAL-c559t-d522a1a4482612f3cb663178d287b6f97cd35906bef6d5bab7b9fa6c2379b56c3</originalsourceid><addsrcrecordid>eNp9kUtvEzEUhS0EomlhzQYhq4uymtaP8QupixIVilRUhMLasj0eMtFkHGwPJf8ejxI1pQtWV7r3O0f36ADwBqNzjAS92AwmnSOGEMEUI_IMzDBSuOK1Qs_BrKxFJWtSH4HjlFYIIcUkegmOMBMYSa5mYH49NMFtc0hdgqGFX_3aRjN4-N07v8khpg9wcR_gN5OX92ab4FX08KPP2Ue4WJoB3g3-FXjRmj751_t5An58ul7Mb6rbu89f5le3lWNM5aphhBhs6loSjklLneWcYiEbIoXlrRKuoUwhbn3LG2aNFVa1hjtChbKMO3oCLne-m9GufeP8kKPp9SZ2axO3OphO_3sZuqX-GX5rVqtayaI_2-tj-DX6lPW6S873fckbxqS5qDliUhXw9Am4CmMcSjZNEKaSYjJBFzvIxZBS9O3DIxjpqRw9laMP5RTFu8f_H_h9G4-ASXmwI1pqwsUEvP8voNux77P_kwv5dkeuUinxAaW0ZCxGfwHroqus</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>201383129</pqid></control><display><type>article</type><title>Endocytosis of Membrane Receptors: Two Pathways Are Better Than One</title><source>JSTOR Archival Journals</source><source>PubMed Central</source><creator>Aguilar, Rubén Claudio ; Wendland, Beverly</creator><creatorcontrib>Aguilar, Rubén Claudio ; Wendland, Beverly</creatorcontrib><description>Aguilar and Wendland discuss two studies that show how Ub can act as an endocytic signal in mammalian cells; in the absence of clathrin, Ub can direct entry via a CIE pathway. It appears that endocytic factors may play multiple roles, depending on which signal the cargo protein presents, or which endocytic route is being used.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.0500213102</identifier><identifier>PMID: 15710869</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>Cell membranes ; Clathrin - physiology ; Commentaries ; Endocytosis ; Eukaryotes ; Freight ; Humans ; Internalization ; Ligands ; Membranes ; Physiological regulation ; Proteins ; Rafts ; Receptors ; Receptors, Cell Surface - metabolism ; Signal transduction ; Ubiquitin - metabolism</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2005-02, Vol.102 (8), p.2679-2680</ispartof><rights>Copyright 1993/2005 The National Academy of Sciences of the United States of America</rights><rights>Copyright National Academy of Sciences Feb 22, 2005</rights><rights>Copyright © 2005, The National Academy of Sciences 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c559t-d522a1a4482612f3cb663178d287b6f97cd35906bef6d5bab7b9fa6c2379b56c3</citedby><cites>FETCH-LOGICAL-c559t-d522a1a4482612f3cb663178d287b6f97cd35906bef6d5bab7b9fa6c2379b56c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/102/8.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3374679$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3374679$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793,58238,58471</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15710869$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aguilar, Rubén Claudio</creatorcontrib><creatorcontrib>Wendland, Beverly</creatorcontrib><title>Endocytosis of Membrane Receptors: Two Pathways Are Better Than One</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Aguilar and Wendland discuss two studies that show how Ub can act as an endocytic signal in mammalian cells; in the absence of clathrin, Ub can direct entry via a CIE pathway. It appears that endocytic factors may play multiple roles, depending on which signal the cargo protein presents, or which endocytic route is being used.</description><subject>Cell membranes</subject><subject>Clathrin - physiology</subject><subject>Commentaries</subject><subject>Endocytosis</subject><subject>Eukaryotes</subject><subject>Freight</subject><subject>Humans</subject><subject>Internalization</subject><subject>Ligands</subject><subject>Membranes</subject><subject>Physiological regulation</subject><subject>Proteins</subject><subject>Rafts</subject><subject>Receptors</subject><subject>Receptors, Cell Surface - metabolism</subject><subject>Signal transduction</subject><subject>Ubiquitin - metabolism</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNp9kUtvEzEUhS0EomlhzQYhq4uymtaP8QupixIVilRUhMLasj0eMtFkHGwPJf8ejxI1pQtWV7r3O0f36ADwBqNzjAS92AwmnSOGEMEUI_IMzDBSuOK1Qs_BrKxFJWtSH4HjlFYIIcUkegmOMBMYSa5mYH49NMFtc0hdgqGFX_3aRjN4-N07v8khpg9wcR_gN5OX92ab4FX08KPP2Ue4WJoB3g3-FXjRmj751_t5An58ul7Mb6rbu89f5le3lWNM5aphhBhs6loSjklLneWcYiEbIoXlrRKuoUwhbn3LG2aNFVa1hjtChbKMO3oCLne-m9GufeP8kKPp9SZ2axO3OphO_3sZuqX-GX5rVqtayaI_2-tj-DX6lPW6S873fckbxqS5qDliUhXw9Am4CmMcSjZNEKaSYjJBFzvIxZBS9O3DIxjpqRw9laMP5RTFu8f_H_h9G4-ASXmwI1pqwsUEvP8voNux77P_kwv5dkeuUinxAaW0ZCxGfwHroqus</recordid><startdate>20050222</startdate><enddate>20050222</enddate><creator>Aguilar, Rubén Claudio</creator><creator>Wendland, Beverly</creator><general>National Academy of Sciences</general><general>National Acad Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20050222</creationdate><title>Endocytosis of Membrane Receptors: Two Pathways Are Better Than One</title><author>Aguilar, Rubén Claudio ; Wendland, Beverly</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c559t-d522a1a4482612f3cb663178d287b6f97cd35906bef6d5bab7b9fa6c2379b56c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Cell membranes</topic><topic>Clathrin - physiology</topic><topic>Commentaries</topic><topic>Endocytosis</topic><topic>Eukaryotes</topic><topic>Freight</topic><topic>Humans</topic><topic>Internalization</topic><topic>Ligands</topic><topic>Membranes</topic><topic>Physiological regulation</topic><topic>Proteins</topic><topic>Rafts</topic><topic>Receptors</topic><topic>Receptors, Cell Surface - metabolism</topic><topic>Signal transduction</topic><topic>Ubiquitin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aguilar, Rubén Claudio</creatorcontrib><creatorcontrib>Wendland, Beverly</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aguilar, Rubén Claudio</au><au>Wendland, Beverly</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endocytosis of Membrane Receptors: Two Pathways Are Better Than One</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>2005-02-22</date><risdate>2005</risdate><volume>102</volume><issue>8</issue><spage>2679</spage><epage>2680</epage><pages>2679-2680</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>Aguilar and Wendland discuss two studies that show how Ub can act as an endocytic signal in mammalian cells; in the absence of clathrin, Ub can direct entry via a CIE pathway. It appears that endocytic factors may play multiple roles, depending on which signal the cargo protein presents, or which endocytic route is being used.</abstract><cop>United States</cop><pub>National Academy of Sciences</pub><pmid>15710869</pmid><doi>10.1073/pnas.0500213102</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0027-8424
ispartof Proceedings of the National Academy of Sciences - PNAS, 2005-02, Vol.102 (8), p.2679-2680
issn 0027-8424
1091-6490
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_549498
source JSTOR Archival Journals; PubMed Central
subjects Cell membranes
Clathrin - physiology
Commentaries
Endocytosis
Eukaryotes
Freight
Humans
Internalization
Ligands
Membranes
Physiological regulation
Proteins
Rafts
Receptors
Receptors, Cell Surface - metabolism
Signal transduction
Ubiquitin - metabolism
title Endocytosis of Membrane Receptors: Two Pathways Are Better Than One
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T09%3A20%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Endocytosis%20of%20Membrane%20Receptors:%20Two%20Pathways%20Are%20Better%20Than%20One&rft.jtitle=Proceedings%20of%20the%20National%20Academy%20of%20Sciences%20-%20PNAS&rft.au=Aguilar,%20Rub%C3%A9n%20Claudio&rft.date=2005-02-22&rft.volume=102&rft.issue=8&rft.spage=2679&rft.epage=2680&rft.pages=2679-2680&rft.issn=0027-8424&rft.eissn=1091-6490&rft_id=info:doi/10.1073/pnas.0500213102&rft_dat=%3Cjstor_pubme%3E3374679%3C/jstor_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c559t-d522a1a4482612f3cb663178d287b6f97cd35906bef6d5bab7b9fa6c2379b56c3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=201383129&rft_id=info:pmid/15710869&rft_jstor_id=3374679&rfr_iscdi=true