Antimalarial Drug Resistance: A Threat to Malaria Elimination

Increasing antimalarial drug resistance once again threatens effective antimalarial drug treatment, malaria control, and elimination. Artemisinin combination therapies (ACTs) are first-line treatment for uncomplicated falciparum malaria in all endemic countries, yet partial resistance to artemisinin...

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Bibliographic Details
Published in:Cold Spring Harbor perspectives in medicine 2017-07, Vol.7 (7), p.a025619
Main Authors: Menard, Didier, Dondorp, Arjen
Format: Article
Language:English
Subjects:
Antigens, Bacterial
Antigens, Bacterial - genetics
Antigens, Surface
Antigens, Surface - genetics
Antimalarials
Antimalarials - pharmacology
Artemisinins
Artemisinins - pharmacology
Drug Resistance
Drug Resistance - genetics
Drug Therapy, Combination
Human health and pathology
Humans
Infectious diseases
Life Sciences
Malaria, Falciparum
Malaria, Falciparum - drug therapy
Malaria, Vivax
Malaria, Vivax - drug therapy
Plasmodium
Plasmodium - drug effects
Plasmodium - genetics
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Summary:Increasing antimalarial drug resistance once again threatens effective antimalarial drug treatment, malaria control, and elimination. Artemisinin combination therapies (ACTs) are first-line treatment for uncomplicated falciparum malaria in all endemic countries, yet partial resistance to artemisinins has emerged in the Greater Mekong Subregion. Concomitant emergence of partner drug resistance is now causing high ACT treatment failure rates in several areas. Genetic markers for artemisinin resistance and several of the partner drugs have been established, greatly facilitating surveillance. Single point mutations in the gene coding for the Kelch propeller domain of the K13 protein strongly correlate with artemisinin resistance. Novel regimens and strategies using existing antimalarial drugs will be needed until novel compounds can be deployed. Elimination of artemisinin resistance will imply elimination of all falciparum malaria from the same areas. In vivax malaria, chloroquine resistance is an increasing problem.
ISSN:2157-1422
2472-5412
DOI:10.1101/cshperspect.a025619