Genetic ancestry and prostate cancer susceptibility SNPs in Puerto Rican and African American men

• Published in: The Prostate 2017-07, Vol.77 (10), p.1118-1127
• Main Authors: Irizarry‐Ramírez, Margarita, Kittles, Rick A., Wang, Xuemei, Salgado‐Montilla, Jeannette, Nogueras‐González, Graciela M., Sánchez‐Ortiz, Ricardo, Guerrios, Lourdes, Rivera, Keila, Shah, Ebony, Prokhorova, Ina, Roberson, Pamela, Troncoso, Patricia, Pettaway, Curtis A.
• Format: Article
• Language: English
• Subjects: Aged; Alleles; Black or African American - genetics; Chromosome 8; comparative; Deoxyribonucleic acid; DNA; Genetic Association Studies; Genetic Predisposition to Disease; hispanic; Hispanic or Latino - genetics; Humans; Male; Middle Aged; Neoplasm Grading; Neoplasm Staging; Paraffin; Polymorphism, Single Nucleotide; Prostate - pathology; Prostate cancer; Prostatectomy - methods; Prostatic Neoplasms - ethnology; Prostatic Neoplasms - genetics; Prostatic Neoplasms - pathology; Rectum; Seminal vesicle; Single-nucleotide polymorphism; understudied; United States - epidemiology
• ISSN: 0270-4137; 1097-0045
• DOI: 10.1002/pros.23368

Background The Puerto Rican (PR) population is a racially admixed population that has a high prostate cancer (PCa) mortality rate. We hypothesized in this pilot study that West African Ancestry (WAA) was associated with PCa in this heterogeneous (PR) population. Methods A case/case and case/control study was performed. Controls, 207 African American (AA) and 133 PR were defined as men with no PCa, a serum PSA  pT2) PCa. Statistical analyses were done using SAS. Results No difference in overall percent WAA was found between PR cases and controls. Among PR or AA cases WAA was not associated with disease severity based upon risk group, Gleason score or stage. Among AA controls WAA was significantly higher than in cases. The SNP rs7824364 (chromosome 8q24) PCa risk allele was significantly increased among cases versus controls for both AA (P