Deletion of the murine ATP/UTP receptor P2Y2 alters mechanical and thermal response properties in polymodal cutaneous afferents

Highlights • We examine the impact of P2Y2 gene deletion on response properties of cutaneous sensory neurons. • Loss of P2Y2 results in reduced firing to noxious heat in polymodal C-fibers. • P2Y2−/− mice show an atypical population of mechanically sensitive afferents expressing TRPV1. • Results ind...

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Bibliographic Details
Published in:Neuroscience 2016-09, Vol.332, p.223-230
Main Authors: Molliver, Derek C, Rau, Kristofer K, Jankowski, Michael P, Soneji, Deepak J, Baumbauer, Kyle M, Richard Koerber, H
Format: Article
Language:English
Subjects:
Action Potentials - physiology
Animals
Ganglia, Spinal - cytology
Ganglia, Spinal - metabolism
Hindlimb - innervation
Hindlimb - metabolism
Hot Temperature
hyperalgesia
Immunohistochemistry
Male
Mechanoreceptors - cytology
Mechanoreceptors - metabolism
metabotropic
Mice, Inbred C57BL
Mice, Knockout
Nerve Fibers, Unmyelinated - metabolism
Neurology
pain
Physical Stimulation
purinergic
Receptors, Purinergic P2Y2 - genetics
Receptors, Purinergic P2Y2 - metabolism
Sensory Thresholds - physiology
Skin - innervation
Skin - metabolism
Spinal Cord - cytology
Spinal Cord - metabolism
Thermoreceptors - cytology
Thermoreceptors - metabolism
Tissue Culture Techniques
TRPV Cation Channels - metabolism
TRPV1
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Summary:Highlights • We examine the impact of P2Y2 gene deletion on response properties of cutaneous sensory neurons. • Loss of P2Y2 results in reduced firing to noxious heat in polymodal C-fibers. • P2Y2−/− mice show an atypical population of mechanically sensitive afferents expressing TRPV1. • Results indicate a role for P2Y2 in determining response properties of cutaneous sensory neurons.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2016.06.054