Midterm eGFR and Adverse Pregnancy Outcomes: The Clinical Significance of Gestational Hyperfiltration

Although hemodynamic adaptation plays a crucial role in maintaining gestation, the clinical significance of midterm renal hyperfiltration (MRH) on pregnancy outcomes is unknown. This was an observational cohort study. Women with a singleton pregnancy and a serum creatinine measurement during their s...

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Bibliographic Details
Published in:Clinical journal of the American Society of Nephrology 2017-07, Vol.12 (7), p.1048-1056
Main Authors: Park, Sehoon, Lee, Seung Mi, Park, Joong Shin, Hong, Joon-Seok, Chin, Ho Jun, Na, Ki Young, Kim, Dong Ki, Oh, Kook-Hwan, Joo, Kwon Wook, Kim, Yon Su, Lee, Hajeong
Format: Article
Language:English
Subjects:
Adult
Biomarkers - blood
Birth Weight
Chi-Square Distribution
Creatinine - blood
Female
Gestational Age
Glomerular Filtration Rate
Hospitals, University
Humans
Infant, Low Birth Weight
Infant, Premature
Kidney - physiopathology
Kidney Diseases - blood
Kidney Diseases - complications
Kidney Diseases - diagnosis
Kidney Diseases - physiopathology
Logistic Models
Multivariate Analysis
Nonlinear Dynamics
Odds Ratio
Original
Pregnancy
Pregnancy Complications - blood
Pregnancy Complications - diagnosis
Pregnancy Complications - physiopathology
Pregnancy Outcome
Pregnancy Trimester, Second
Premature Birth - etiology
Premature Birth - physiopathology
Risk Factors
Seoul
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Summary:Although hemodynamic adaptation plays a crucial role in maintaining gestation, the clinical significance of midterm renal hyperfiltration (MRH) on pregnancy outcomes is unknown. This was an observational cohort study. Women with a singleton pregnancy and a serum creatinine measurement during their second trimester were followed at two university hospitals in Korea between 2001 and 2015. Those with substantial renal function impairment or who delivered during the second trimester were not considered. MRH was represented by the highest eGFR, which was calculated using the Chronic Kidney Disease Epidemiology Collaboration method. An adverse pregnancy event was defined by the composition of preterm birth (gestational age
ISSN:1555-9041
1555-905X
DOI:10.2215/CJN.12101116