Hepatoprotective Effect of Citral on Acetaminophen-Induced Liver Toxicity in Mice

High doses of acetaminophen (APAP) lead to acute liver damage. In this study, we evaluated the effects of citral in a murine model of hepatotoxicity induced by APAP. The liver function markers alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and gamma-glu...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2017-01, Vol.2017 (2017), p.1-9
Main Authors: Cuman, Roberto Kenji Nakamura, Silva, Expedito Leite, Silva-Comar, Francielli Maria de Souza, Cremer, Edivaldo, Cardia, Gabriel Fernando Esteves, Silva-Filho, Saulo Euclides, Uchida, Nancy Sayuri, Bersani-Amado, Ciomar Aparecida
Format: Article
Language:English
Subjects:
Acetaminophen
Alternative medicine
Analysis
Aromatic compounds
Complications and side effects
Health aspects
Kinases
Liver
Liver diseases
Methods
Physiological aspects
Prevention
Risk factors
Rodents
Studies
Terpenes
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Summary:High doses of acetaminophen (APAP) lead to acute liver damage. In this study, we evaluated the effects of citral in a murine model of hepatotoxicity induced by APAP. The liver function markers alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and gamma-glutamyl transferase (γGT) were determined to evaluate the hepatoprotective effects of citral. The livers were used to determine myeloperoxidase (MPO) activity and nitric oxide (NO) production and in histological analysis. The effect of citral on leukocyte migration and antioxidant activity was evaluated in vitro. Citral pretreatment decreased significantly the levels of ALT, AST, ALP, and γGT, MPO activity, and NO production. The histopathological analysis showed an improvement of hepatic lesions in mice after citral pretreatment. Citral inhibited neutrophil migration and exhibited antioxidant activity. Our results suggest that citral protects the liver against liver toxicity induced by APAP.
ISSN:1741-427X
1741-4288
DOI:10.1155/2017/1796209