Diet high in fructose promotes liver steatosis and hepatocyte apoptosis in C57BL/6J female mice: Role of disturbed lipid homeostasis and increased oxidative stress

• Published in: Food and chemical toxicology 2017-05, Vol.103, p.111-121
• Main Authors: Choi, Youngshim, Abdelmegeed, Mohamed A., Song, Byoung-Joon
• Format: Article
• Language: English
• Subjects: adipose tissue; Animals; apoptosis; Apoptosis - drug effects; blood serum; Body Weight - drug effects; cholesterol; diet; fas Receptor - metabolism; fatty acids; fatty liver; Female; females; fructose; Fructose - adverse effects; Glutathione - metabolism; hepatocytes; Hepatocytes - drug effects; Hepatocytes - metabolism; Hepatocytes - pathology; homeostasis; inducible nitric oxide synthase; inflammation; Lipid Metabolism - drug effects; lipolysis; macrophages; mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type II - metabolism; Non-alcoholic Fatty Liver Disease - chemically induced; Non-alcoholic Fatty Liver Disease - pathology; oxidative stress; Oxidative Stress - drug effects; Panniculitis - chemically induced; Panniculitis - metabolism; Stearoyl-CoA Desaturase - metabolism; toxicology; triacylglycerol lipase; triacylglycerols; Triglycerides - blood; Triglycerides - metabolism; tumor necrosis factor-alpha
• ISSN: 0278-6915; 1873-6351
• DOI: 10.1016/j.fct.2017.02.039

The effects of high (H)-fructose (FR) diet (D) (HFRD) on hepatic lipid homeostasis, oxidative stress, inflammation and hepatocyte apoptosis were investigated in 6-week old female C57BL/6J mice fed a regular chow (ContD) or HFRD (35% fructose-derived calories) for 3 weeks. HFRD-fed mice exhibited increased levels of hepatic steatosis with a significant elevation of serum levels of triglyceride, cholesterol and TNFα compared to ContD-fed mice (P