Treatment of severe mucositis pain with oral ketamine mouthwash

Purpose Mucositis is a significant complication of intensive chemotherapy or hematopoietic cell transplantation (HCT), with few treatment options. Ketamine mouthwashes have been used for pain relief, but supporting evidence is limited. The primary objective of this study was to assess the reduction...

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Bibliographic Details
Published in:Supportive care in cancer 2017-07, Vol.25 (7), p.2215-2219
Main Authors: Shillingburg, Alexandra, Kanate, Abraham S., Hamadani, Mehdi, Wen, Sijin, Craig, Michael, Cumpston, Aaron
Format: Article
Language:English
Subjects:
Adult
Aged
Chemotherapy
Comparative analysis
Disease management
Female
Hematopoietic stem cell transplantation
Hematopoietic Stem Cell Transplantation - adverse effects
Humans
Ketamine
Ketamine - therapeutic use
Male
Medicine
Medicine & Public Health
Middle Aged
Mouthwashes - therapeutic use
Mucositis - drug therapy
Mucositis - etiology
Nursing
Nursing Research
Oncology
Oral hygiene
Original Article
Pain
Pain - drug therapy
Pain - etiology
Pain management
Pain Medicine
Prospective Studies
Rehabilitation Medicine
Stomatitis - complications
Stomatitis - drug therapy
Toiletries industry
Young Adult
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Summary:Purpose Mucositis is a significant complication of intensive chemotherapy or hematopoietic cell transplantation (HCT), with few treatment options. Ketamine mouthwashes have been used for pain relief, but supporting evidence is limited. The primary objective of this study was to assess the reduction in pain intensity of stomatodynia and odynophagia compared to baseline assessment. Methods This open-label, prospective, phase II interventional study (NCT01566448) was conducted from February 2012 through July 2015. Patients with grade 3 or 4 oral mucositis according to the World Health Organization (WHO) scale as a result of chemotherapy were treated with ketamine mouthwash 20 mg/5 mL four times daily and every 4 h as needed. Results Thirty patients were enrolled and a total of 136 assessments were conducted. A statistically significant reduction in pain scores of 2 and 3 points was achieved after 1 h and 3 days, respectively ( p  
ISSN:0941-4355
1433-7339
DOI:10.1007/s00520-017-3627-6