A Genetic Study of the Anesthetic Response: Mutants of Drosophila melanogaster Altered in Sensitivity to Halothane

In an attempt to identify genes that control or encode the targets of general anesthetics, we have chemically mutagenized fruit flies and selected four lines that show an abnormal response to the volatile anesthetic halothane. Specifically, about 2-fold higher concentrations of halothane are require...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1990-11, Vol.87 (21), p.8632-8636
Main Authors: Krishnan, K. S., Nash, Howard A.
Format: Article
Language:English
Subjects:
Anesthesia
Anesthetics
Animals
Biological and medical sciences
Chromosome Mapping
Classical genetics, quantitative genetics, hybrids
Diptera
Dose-Response Relationship, Drug
Drosophila
Drosophila melanogaster - drug effects
Drosophila melanogaster - genetics
Drosophilidae
Drug Resistance - genetics
Female
Fundamental and applied biological sciences. Psychology
Genetic loci
Genetics of eukaryotes. Biological and molecular evolution
Halothane - pharmacology
Invertebrata
Medical genetics
Mutation
Nervous system
Phenotypes
Separators
Sex chromosomes
Time Factors
X Chromosome
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Summary:In an attempt to identify genes that control or encode the targets of general anesthetics, we have chemically mutagenized fruit flies and selected four lines that show an abnormal response to the volatile anesthetic halothane. Specifically, about 2-fold higher concentrations of halothane are required to induce the loss of motor control in the mutant flies. Fine mapping of two isolates indicates that they alter a previously uncharacterized gene of Drosophila. In the absence of anesthetics, these mutants display alterations of behavior that imply changes in the adult and the larval neuromuscular system.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.87.21.8632