Linarin Enriched Extract Attenuates Liver Injury and Inflammation Induced by High-Fat High-Cholesterol Diet in Rats

The aim of this study was to explore the potential beneficial effects of linarin enriched Flos Chrysanthemi extract (Lin-extract) on nonalcoholic steatohepatitis (NASH) induced by high-fat high-cholesterol (HFHC) diet in rats. SD rats received normal diet, HFHC diet, or HFHC diet plus different dose...

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Published in:Evidence-based complementary and alternative medicine 2017-01, Vol.2017 (2017), p.1-9
Main Authors: Chen, Su-Hong, Shi, Jun-ping, Lv, Gui-Yuan, Song, Yu, Liu, Yin-lan, Luo, Yan, Wang, Han, Pang, Min-Xia, Li, Bo, Shan, Chao-Wen, Zhuang, Zhen-Jie, Wang, Nan-Nan
Format: Article
Language:English
Subjects:
Biochemistry
Chinese medicine
Cholesterol
Diet
Fatty acids
Flavonoids
Health aspects
Hepatitis B
Hypertension
Inflammation
Kinases
Laboratory animals
Lipids
Liver diseases
Low density lipoprotein
Materia medica, Vegetable
Metabolic syndrome
Plant extracts
Prevention
Proteins
Risk factors
Rodents
Tumor necrosis factor-TNF
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Summary:The aim of this study was to explore the potential beneficial effects of linarin enriched Flos Chrysanthemi extract (Lin-extract) on nonalcoholic steatohepatitis (NASH) induced by high-fat high-cholesterol (HFHC) diet in rats. SD rats received normal diet, HFHC diet, or HFHC diet plus different doses of Lin-extract. The liver content of triglyceride and total cholesterol markedly increased in HFHC diet-fed model rats while middle and high dose of Lin-extract lowered liver cholesterol significantly. The expression of stearoyl-CoA desaturase (SCD1) was upregulated by HFHC diet and further elevated by high dose Lin-extract. High dose of Lin-extract also markedly lowered the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and inhibited the activation of c-Jun N-terminal kinase (JNK) induced by HFHC in livers. The HFHC-increased mRNA levels of hepatic inflammation cytokines, including monocyte chemotactic protein-1 (MCP-1), tumor necrosis factor-α (TNF-α), and chemokine (C-X-C motif) ligand 1 (CXCL1), were suppressed by Lin-extract dose-dependently. Furthermore, pathology evaluation showed that high dose Lin-extract greatly improved lobular inflammation. Our results suggest that Lin-extract could attenuate liver injury and inflammation induced by HFHC diet in rats. Its modulatory effect on lipid metabolism may partially contribute to this protective effect.
ISSN:1741-427X
1741-4288
DOI:10.1155/2017/4701570