Recurrent Body Rash Warranted Second Desensitization With Acyclovir in a Myeloma Patient: A Case Report

A 75-year-old woman developed a moderately severe rash about a week and a half after the start of bortezomib (Btb)-based chemotherapy for IgG lambda multiple myeloma; at the time, she was also receiving acyclovir as antiviral prophylaxis in addition to herpes zoster (HZ) vaccination. HZ reactivation...

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Bibliographic Details
Published in:Journal of clinical medicine research 2017-08, Vol.9 (8), p.725-728
Main Authors: Seki, Jack T, Ng, Pamela, Lam, Wallace, Cote, Julie, Prica, Anca
Format: Article
Language:English
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Case Report
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Summary:A 75-year-old woman developed a moderately severe rash about a week and a half after the start of bortezomib (Btb)-based chemotherapy for IgG lambda multiple myeloma; at the time, she was also receiving acyclovir as antiviral prophylaxis in addition to herpes zoster (HZ) vaccination. HZ reactivation rate is high in Btb recipients; therefore, the timing of antiviral prevention is critical in relation to Btb. Attempts were made to identify the offending agent based on the timing of drugs administered and the appearance of skin lesions in relation to other drugs. Both Btb and acyclovir were potential culprits. However, the timing of rash presented on days 9 - 10 revealed the offending agent when the corticosteroid was weaned off while acyclovir continued. A decision was made to administer acyclovir rapid desensitization program (RDP) for our patient.
ISSN:1918-3003
1918-3011
DOI:10.14740/jocmr2772w