Effects of calcium channel blocker benidipine-based combination therapy on target blood pressure control and cardiovascular outcome: a sub-analysis of the COPE trial

We compared three benidipine-based regimens-that is, benidipine plus angiotensin receptor blocker (ARB), β-blocker (BB) or thiazide-and found that the benidipine-BB combination was less beneficial in reducing the risk of stroke than the benidipine-thiazide combination. This sub-analysis sought to co...

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Bibliographic Details
Published in:Hypertension research 2017-04, Vol.40 (4), p.376-384
Main Authors: Umemoto, Seiji, Ogihara, Toshio, Matsuzaki, Masunori, Rakugi, Hiromi, Ohashi, Yasuo, Saruta, Takao
Format: Article
Language:English
Subjects:
Aged
Antihypertensive Agents - pharmacology
Antihypertensive Agents - therapeutic use
Blood Pressure - drug effects
Blood Pressure Determination
Calcium Channel Blockers - pharmacology
Calcium Channel Blockers - therapeutic use
Dihydropyridines - pharmacology
Dihydropyridines - therapeutic use
Drug Therapy, Combination
Female
Heart Rate - drug effects
Humans
Hypertension - drug therapy
Male
Middle Aged
Original
Sodium Chloride Symporter Inhibitors - pharmacology
Sodium Chloride Symporter Inhibitors - therapeutic use
Treatment Outcome
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Summary:We compared three benidipine-based regimens-that is, benidipine plus angiotensin receptor blocker (ARB), β-blocker (BB) or thiazide-and found that the benidipine-BB combination was less beneficial in reducing the risk of stroke than the benidipine-thiazide combination. This sub-analysis sought to compare the effects of reaching a target blood pressure (BP) (
ISSN:0916-9636
1348-4214
DOI:10.1038/hr.2016.158