Enzyme-Responsive Liposomes for the Delivery of Anticancer Drugs

Liposomes are nanocarriers that deliver the payloads at the target site, leading to therapeutic drug concentrations at the diseased site and reduced toxic effects in healthy tissues. Several approaches have been used to enhance the ability of the nanocarrier to target the specific tissues, including...

Full description

Saved in:
Bibliographic Details
Published in:Bioconjugate chemistry 2017-04, Vol.28 (4), p.857-868
Main Authors: Fouladi, Farnaz, Steffen, Kristine J, Mallik, Sanku
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - administration & dosage
Antineoplastic drugs
Antitumor agents
Biocatalysis
Cargo
Cathepsin B - metabolism
Cellular structure
Delayed-Action Preparations - chemistry
Delayed-Action Preparations - metabolism
Destabilization
Drug delivery
Drug delivery systems
Drug Delivery Systems - methods
Enzymes
Humans
Ligands
Lipids
Lipopeptides - chemistry
Lipopeptides - metabolism
Liposomes
Liposomes - chemistry
Liposomes - metabolism
Matrix Metalloproteinases - metabolism
Neoplasms - drug therapy
Pancreatic Elastase - metabolism
Payloads
Peptides
Phospholipases A2, Secretory - metabolism
Polymers
Polymers - chemistry
Polymers - metabolism
Prodrugs - administration & dosage
Prostate-Specific Antigen - metabolism
Stimuli
Tissues
Urokinase-Type Plasminogen Activator - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Liposomes are nanocarriers that deliver the payloads at the target site, leading to therapeutic drug concentrations at the diseased site and reduced toxic effects in healthy tissues. Several approaches have been used to enhance the ability of the nanocarrier to target the specific tissues, including ligand-targeted liposomes and stimuli-responsive liposomes. Ligand-targeted liposomes exhibit higher uptake by the target tissue due to the targeting ligand attached to the surface, while the stimuli-responsive liposomes do not release their cargo unless they expose to an endogenous or exogenous stimulant at the target site. In this review, we mainly focus on the liposomes that are responsive to pathologically increased levels of enzymes at the target site. Enzyme-responsive liposomes release their cargo upon contact with the enzyme through several destabilization mechanisms: (1) structural perturbation in the lipid bilayer, (2) removal of a shielding polymer from the surface and increased cellular uptake, (3) cleavage of a lipopeptide or lipopolymer incorporated in the bilayer, and (4) activation of a prodrug in the liposomes.
ISSN:1043-1802
1520-4812
DOI:10.1021/acs.bioconjchem.6b00736