Peripheral Antinociception Induced by Aripiprazole Is Mediated by the Opioid System

Background. Aripiprazole is an antipsychotic drug used to treat schizophrenia and related disorders. Our previous study showed that this compound also induces antinociceptive effects. The present study aimed to assess the participation of the opioid system in this effect. Methods. Male Swiss mice we...

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Bibliographic Details
Published in:BioMed research international 2017-01, Vol.2017 (2017), p.1-6
Main Authors: Moreira, Fabrício de Araújo, Aguiar, Daniele C., Duarte, Igor Dimitri Gama, Almeida-Santos, Ana Flávia, Ferreira, Renata Cristina Mendes, Romero, Thiago Roberto Lima
Format: Article
Language:English
Subjects:
Analgesics - pharmacology
Animals
Aripiprazole
Aripiprazole - pharmacology
Dinoprostone - metabolism
Dopamine
Dosage and administration
Drug dosages
Drug interactions
Endorphins
Experiments
Hyperalgesia - drug therapy
Hyperalgesia - metabolism
Male
Mice
Narcotics
Observations
Pain
Pharmaceuticals
Proteins
Receptors, Opioid - metabolism
Rodents
Signal transduction
Studies
Variance analysis
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Summary:Background. Aripiprazole is an antipsychotic drug used to treat schizophrenia and related disorders. Our previous study showed that this compound also induces antinociceptive effects. The present study aimed to assess the participation of the opioid system in this effect. Methods. Male Swiss mice were submitted to paw pressure test and hyperalgesia was induced by intraplantar injection of prostaglandin E2 (PGE2, 2 μg). Aripiprazole was injected 10 min before the measurement. Naloxone, clocinnamox, naltrindole, nor-binaltorphimine, and bestatin were given 30 min before aripiprazole. Nociceptive thresholds were measured in the 3rd hour after PGE2 injection. Results. Aripiprazole (100 μg/paw) injected locally into the right hind paw induced an antinociceptive effect that was blocked by naloxone (50 μg/paw), a nonselective opioid receptor antagonist. The role of μ-, δ-, and κ-opioid receptors was investigated using the selective antagonists, clocinnamox (40 μg/paw), naltrindole (15, 30, and 60 μg/paw), and nor-binaltorphimine (200 μg/paw), respectively. The data indicated that only the δ-opioid receptor antagonist inhibited the peripheral antinociception induced by aripiprazole. Bestatin (400 μg), an aminopeptidase-N inhibitor, significantly enhanced low-dose (25 μg/paw) aripiprazole-induced peripheral antinociception. Conclusion. The results suggest the participation of the opioid system via δ-opioid receptor in the peripheral antinociceptive effect induced by aripiprazole.
ISSN:2314-6133
2314-6141
DOI:10.1155/2017/8109205