The Parathyroid Gland and Heart Disease

The parathyroid glands are critical to maintaining calcium homeostasis through actions of parathyroid hormone (PTH). Recent clinical and molecular research has shown that direct and indirect actions of PTH also affect the heart and vasculature through downstream actions of G protein-coupled receptor...

Full description

Saved in:
Bibliographic Details
Published in:Methodist DeBakey cardiovascular journal 2017-04, Vol.13 (2), p.49-54
Main Authors: Brown, Spandana J, Ruppe, Mary D, Tabatabai, Laila S
Format: Article
Language:English
Subjects:
Heart - physiopathology
Heart Diseases - diagnosis
Heart Diseases - epidemiology
Heart Diseases - physiopathology
Heart Diseases - prevention & control
Humans
Parathyroid Diseases - diagnosis
Parathyroid Diseases - epidemiology
Parathyroid Diseases - physiopathology
Parathyroid Diseases - therapy
Parathyroid Glands - physiopathology
Prognosis
Risk Assessment
Risk Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The parathyroid glands are critical to maintaining calcium homeostasis through actions of parathyroid hormone (PTH). Recent clinical and molecular research has shown that direct and indirect actions of PTH also affect the heart and vasculature through downstream actions of G protein-coupled receptors in the myocardium and endothelial cells. Patients with disorders of the parathyroid gland have higher incidences of hypertension, arrhythmias, left ventricular hypertrophy, heart failure, and calcific disease which translate into increased cardiac morbidity and mortality. Importantly, clinical research also suggests that early treatment of parathyroid disorders through medical or surgical management may reverse cardiovascular remodeling and mitigate cardiac risk factors.
ISSN:1947-6094
1947-6108
DOI:10.14797/mdcj-13-2-49