Controllable Photodynamic Therapy Implemented by Regulating Singlet Oxygen Efficiency

• Published in: Advanced science 2017-07, Vol.4 (7), p.1700113-n/a
• Main Authors: Wu, Wenting, Shao, Xiaodong, Zhao, Jianzhang, Wu, Mingbo
• Format: Article
• Language: English
• Subjects: cancer; photodynamic therapy; photosensitization; Review; Reviews; singlet oxygen
• ISSN: 2198-3844; 2198-3844
• DOI: 10.1002/advs.201700113

With singlet oxygen (1O2) as the active agent, photodynamic therapy (PDT) is a promising technique for the treatment of various tumors and cancers. But it is hampered by the poor selectivity of most traditional photosensitizers (PS). In this review, we present a summary of controllable PDT implemented by regulating singlet oxygen efficiency. Herein, various controllable PDT strategies based on different initiating conditions (such as pH, light, H2O2 and so on) have been summarized and introduced. More importantly, the action mechanisms of controllable PDT strategies, such as photoinduced electron transfer (PET), fluorescence resonance energy transfer (FRET), intramolecular charge transfer (ICT) and some physical/chemical means (e.g. captivity and release), are described as a key point in the article. This review provide a general overview of designing novel PS or strategies for effective and controllable PDT. Recent research progress towards controllable photodynamic therapy implemented by regulating singlet oxygen production efficiency is discussed in this Review. It is focused on the discussion of various design strategies of controllable photosensitizers, from the mechanisms of activatable photosensitizers themselves to their response to the special tumor microenviroments.