Aptamers from Cell-Based Selection for Bioanalytical Applications

The use of aptamers in biomarker discovery, detection and cellular profiling is examined. Aptamers can be derived from cell-systematic evolution of ligands via exponential enrichment, known as SELEX.

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Bibliographic Details
Published in:Chemical reviews 2013-04, Vol.113 (4), p.2842-2862
Main Authors: Tan, Weihong, Donovan, Michael J, Jiang, Jianhui
Format: Article
Language:English
Subjects:
Animals
Aptamers, Nucleotide - chemistry
Aptamers, Nucleotide - metabolism
Biochemistry
Biomarkers
Biomarkers - analysis
Biosensing Techniques
Biosynthesis
Cellular
Enrichment
Evolution
Fluorescence Resonance Energy Transfer
Humans
Immunomagnetic Separation
Ligands
Metal Nanoparticles - chemistry
Microfluidic Analytical Techniques
Peptides
Profiling
SELEX Aptamer Technique
Tissue Array Analysis
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Description
Summary:The use of aptamers in biomarker discovery, detection and cellular profiling is examined. Aptamers can be derived from cell-systematic evolution of ligands via exponential enrichment, known as SELEX.
ISSN:0009-2665
1520-6890
DOI:10.1021/cr300468w