Circ-104916 is downregulated in gastric cancer and suppresses migration and invasion of gastric cancer cells

Circular RNAs are a large class of noncoding RNA that have shown huge capabilities as gene regulators. Recent evidence suggest that circular RNAs are associated with many diseases, especially cancer. However, little attention has been focused on the expression and function of circular RNA in gastric...

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Bibliographic Details
Published in:OncoTargets and therapy 2017-01, Vol.10, p.3521-3529
Main Authors: Li, Jin, Zhen, Li, Zhang, Yan, Zhao, Liying, Liu, Hao, Cai, Danxian, Chen, Hao, Yu, Jiang, Qi, Xiaolong, Li, Guoxin
Format: Article
Language:English
Subjects:
Binding sites
Biomarkers
Care and treatment
Cell adhesion & migration
Cell cycle
Cell growth
Development and progression
Gastric cancer
Gene expression
Genetic aspects
Health aspects
Hospitals
Liver cancer
Original Research
Ovarian cancer
RNA
Stomach cancer
Studies
Surgery
Tumor suppressor genes
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Summary:Circular RNAs are a large class of noncoding RNA that have shown huge capabilities as gene regulators. Recent evidence suggest that circular RNAs are associated with many diseases, especially cancer. However, little attention has been focused on the expression and function of circular RNA in gastric cancer (GC). In this study, we demonstrate that the expression of circ-104916 is downregulated in GC tissues and cell lines. A lower expression of circ-104916 appeared in deeper invasion depth, higher tumor stage and more frequent lymphatic metastasis patients. Overexpression of circ-104916 effectively inhibited the proliferation, migration and invasion abilities of GC cells in vitro. Western blot showed that circ-104916 overexpression upregulated E-cadherin and downregulated N-cadherin, Vimentin and Slug, indicating that circ-104916 was involved in the epithelial-mesenchymal transition process. Our results revealed that circ-104916 might be a novel potential tumor suppressor and biomarker of GC.
ISSN:1178-6930
1178-6930
DOI:10.2147/OTT.S136347