Vibrational Profiling of Brain Tumors and Cells

This study reports vibration profiles of neuronal cells and tissues as well as brain tumor and neocortical specimens. A contact-free method and analysis protocol was designed to convert an atomic force microscope into an ultra-sensitive microphone with capacity to record and listen to live biologica...

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Bibliographic Details
Published in:Theranostics 2017-01, Vol.7 (9), p.2417-2430
Main Authors: Nelson, Sultan L, Proctor, Dustin T, Ghasemloonia, Ahmad, Lama, Sanju, Zareinia, Kourosh, Ahn, Younghee, Al-Saiedy, Mustafa R, Green, Francis Hy, Amrein, Matthias W, Sutherland, Garnette R
Format: Article
Language:English
Subjects:
Animals
Astrocytoma - diagnosis
Astrocytoma - pathology
Brain Neoplasms - diagnosis
Brain Neoplasms - pathology
Diagnostic Tests, Routine - methods
Meningioma - diagnosis
Meningioma - pathology
Neocortex - physiology
Pathology - methods
Rats
Research Paper
Sound
Vibration
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Summary:This study reports vibration profiles of neuronal cells and tissues as well as brain tumor and neocortical specimens. A contact-free method and analysis protocol was designed to convert an atomic force microscope into an ultra-sensitive microphone with capacity to record and listen to live biological samples. A frequency of 3.4 Hz was observed for both cultured rat hippocampal neurons and tissues and vibration could be modulated pharmacologically. Malignant astrocytoma tissue samples obtained from operating room, transported in artificial cerebrospinal fluid, and tested within an hour, vibrated with a much different frequency profile and amplitude, compared to meningioma or lateral temporal cortex providing a quantifiable measurement to accurately distinguish the three tissues in real-time. Vibration signals were converted to audible sound waves by frequency modulation, thus demonstrating, acoustic patterns unique to meningioma, malignant astrocytoma and neocortex.
ISSN:1838-7640
1838-7640
DOI:10.7150/thno.19172