Sivelestat sodium hydrate improves post-traumatic knee osteoarthritis through nuclear factor-κB in a rat model

As a specific inhibitor of neutrophil elastase, sivelestat sodium hydrate has primarily been used in the treatment of acute lung injury caused by various factors since its approval in 2002. Sivelestat sodium hydrate also improves post-traumatic knee osteoarthritis (KOA), although its underlying mech...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2017-08, Vol.14 (2), p.1531-1537
Main Authors: Yu, Xiaofeng, Zhao, Lijun, Yu, Zhiping, Yu, Changzheng, Bi, Jianfei, Sun, Binglong, Cong, Haibo
Format: Article
Language:English
Subjects:
Arthritis
Cytokines
Deoxyribonucleic acid
DNA
Gene expression
Humidity
Inflammation
Middle age
Pain
Pathogenesis
post-traumatic knee osteoarthritis
Protein expression
Proteins
Rodents
Signal transduction
sivelestat sodium hydrate
Sodium
Studies
Transcription factors
Tumor necrosis factor-TNF
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Summary:As a specific inhibitor of neutrophil elastase, sivelestat sodium hydrate has primarily been used in the treatment of acute lung injury caused by various factors since its approval in 2002. Sivelestat sodium hydrate also improves post-traumatic knee osteoarthritis (KOA), although its underlying mechanisms of action have yet to be elucidated. The aim of the current study was to determine if sivelestat sodium hydrate improves post-traumatic KOA through nuclear factor (NF)-κB in a rat model. Treatment with sivelestat sodium hydrate significantly inhibited the induction of structural changes and significantly increased the vertical episode count and ipsilateral static weight bearing of the joint in KOA rats (all P
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2017.4684