Identification of recurrence-related microRNAs in hepatocellular carcinoma following liver transplantation

Tumor recurrence-related microRNAs (miRNAs) in hepatocellular carcinoma (HCC) following orthotopic liver transplantation (OLT) are not clear yet. This study was designed to determine whether altered miRNA expression is associated with HCC recurrence and prognosis following OLT. 18 miRNAs, including...

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Bibliographic Details
Published in:Molecular oncology 2012-08, Vol.6 (4), p.445-457
Main Authors: Han, Zhong-Bo, Zhong, Lin, Teng, Mu-Jian, Fan, Jun-Wei, Tang, Hua-Mei, Wu, Jun-Yi, Chen, Hong-Yuan, Wang, Zhao-Wen, Qiu, Guo-Qiang, Peng, Zhi-Hai
Format: Article
Language:English
Subjects:
Apoptosis
Bioinformatics
Biomarkers
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Carcinoma, Hepatocellular - diagnosis
Carcinoma, Hepatocellular - genetics
Carcinoma, Hepatocellular - pathology
Cell adhesion & migration
Cell cycle
Chemotherapy
Computational Biology
DNA microarrays
Female
Gene expression
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Gene Regulatory Networks - genetics
Hepatitis
Hepatocellular carcinoma
Hospitals
Humans
Kaplan-Meier Estimate
Liver cancer
Liver Neoplasms - diagnosis
Liver Neoplasms - genetics
Liver Neoplasms - pathology
Liver Transplantation
Male
Medical prognosis
Metastasis
MicroRNA
MicroRNAs
MicroRNAs - genetics
MicroRNAs - metabolism
Middle Aged
miRNA
Neoplasm Recurrence, Local - genetics
Neoplasm Recurrence, Local - pathology
Oligonucleotide Array Sequence Analysis
Patients
Prognosis
Proportional Hazards Models
Recurrence
Reproducibility of Results
Reverse Transcriptase Polymerase Chain Reaction
ROC Curve
Signal Transduction - genetics
Studies
Surgery
Survival
Survival Analysis
Tumors
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Description
Summary:Tumor recurrence-related microRNAs (miRNAs) in hepatocellular carcinoma (HCC) following orthotopic liver transplantation (OLT) are not clear yet. This study was designed to determine whether altered miRNA expression is associated with HCC recurrence and prognosis following OLT. 18 miRNAs, including 6 up-regulated and 12 down-regulated miRNAs were identified by microarray in primary HCC samples of patients who had developed HCC recurrence (n = 5) compared to those with non-recurrence (n = 5) following OLT by using p 
ISSN:1574-7891
1878-0261
DOI:10.1016/j.molonc.2012.04.001