In vitro experiments on axon guidance demonstrating an anterior‐posterior gradient on the tectum

Axonal growth cones originating from explants of embryonic chick retina were simultaneously exposed to two different cell monolayers and their preference for particular monolayers as a substrate for growth was determined. These experiments show that: (1) nasal retinal axons can distinguish between r...

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Bibliographic Details
Published in:The EMBO journal 1982, Vol.1 (4), p.427-431
Main Authors: Bonhoeffer, F., Huf, J.
Format: Article
Language:English
Subjects:
Animals
Axonal Transport
Axons - physiology
Chick Embryo
Organ Culture Techniques
Retina - embryology
Retina - transplantation
Superior Colliculi - embryology
Superior Colliculi - physiology
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Summary:Axonal growth cones originating from explants of embryonic chick retina were simultaneously exposed to two different cell monolayers and their preference for particular monolayers as a substrate for growth was determined. These experiments show that: (1) nasal retinal axons can distinguish between retinal and tectal cells; (2) temporal retinal axons can distinguish between tectal cells that originated from different positions within the tectum along the antero‐posterior axis; (3) axons originating from nasal parts of the retina have different recognizing capabilities from temporal axons; (4) the property of the tectal cells, which is attractive for temporal axons, has a graded distribution along the antero‐posterior axis of the tectum; and (5) this gradient also exists in non‐innervated tecta.
ISSN:0261-4189
1460-2075
DOI:10.1002/j.1460-2075.1982.tb01186.x