Drug-Induced Atrial Fibrillation

Atrial fibrillation (AF) is a common cardiac arrhythmia that is associated with severe consequences, including symptoms, haemodynamic instability, increased cardiovascular mortality and stroke. While other arrhythmias such as torsades de pointes and sinus bradycardia are more typically thought of as...

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Bibliographic Details
Published in:Drugs (New York, N.Y.) N.Y.), 2012-08, Vol.72 (12), p.1617-1630
Main Authors: Kaakeh, Yaman, Overholser, Brian R., Lopshire, John C., Tisdale, James E.
Format: Article
Language:English
Subjects:
Adenosine
Adrenergic receptors
Arrhythmias, Cardiac - chemically induced
Atrial Fibrillation - chemically induced
Biological and medical sciences
Biomarkers
Cardiac arrhythmia
Cardiac dysrhythmias
Cardiology. Vascular system
Cardiovascular disease
Drug toxicity and drugs side effects treatment
Drug-Related Side Effects and Adverse Reactions
Drugs
Heart
Heart failure
Humans
Hypertension
Hyperthyroidism
Internal Medicine
Medical sciences
Medicine
Medicine & Public Health
Pharmacology. Drug treatments
Pharmacology/Toxicology
Pharmacotherapy
Review Article
Risk Factors
Toxicity: cardiovascular system
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Summary:Atrial fibrillation (AF) is a common cardiac arrhythmia that is associated with severe consequences, including symptoms, haemodynamic instability, increased cardiovascular mortality and stroke. While other arrhythmias such as torsades de pointes and sinus bradycardia are more typically thought of as drug induced, AF may also be precipitated by drug therapy, although ascribing causality to drug-associated AF is more difficult than with other drug-induced arrhythmias. Drug-induced AF is more likely to occur in patients with risk factors and co-morbidities that commonly co-exist with AF, such as advanced age, alcohol consumption, family history of AF, hypertension, thyroid dysfunction, sleep apnoea and heart disease. New-onset AF has been associated with cardiovascular drugs such as adenosine, dobutamine and milrinone. In addition, medications such as corticosteroids, ondansetron and antineoplastic agents such as paclitaxel, mitoxantrone and doxorubicin have been reported to induce AF. Whether bisphosphonate drugs are associated with new-onset AF remains controversial and requires further study. The potential contribution of specific drug therapy should be considered when patients present with new-onset AF.
ISSN:0012-6667
1179-1950
DOI:10.2165/11633140-000000000-00000