The Impact of Oral Promethazine on Human Whole-Body Motion Perceptual Thresholds

Despite the widespread treatment of motion sickness symptoms using drugs and the involvement of the vestibular system in motion sickness, little is known about the effects of anti-motion sickness drugs on vestibular perception. In particular, the impact of oral promethazine, widely used for treating...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the Association for Research in Otolaryngology 2017-08, Vol.18 (4), p.581-590
Main Authors: Diaz-Artiles, Ana, Priesol, Adrian J., Clark, Torin K., Sherwood, David P., Oman, Charles M., Young, Laurence R., Karmali, Faisal
Format: Article
Language:English
Subjects:
Blindness
Medicine
Medicine & Public Health
Motion detection
Motion sickness
Motor task performance
Neurobiology
Neurosciences
Otorhinolaryngology
Perception
Promethazine
Research Article
Statistical analysis
Translation
Vestibular system
Vestibulo-ocular reflex
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Despite the widespread treatment of motion sickness symptoms using drugs and the involvement of the vestibular system in motion sickness, little is known about the effects of anti-motion sickness drugs on vestibular perception. In particular, the impact of oral promethazine, widely used for treating motion sickness, on vestibular perceptual thresholds has not previously been quantified. We examined whether promethazine (25 mg) alters vestibular perceptual thresholds in a counterbalanced, double-blind, within-subject study. Thresholds were determined using a direction recognition task (left vs. right) for whole-body yaw rotation, y-translation (interaural), and roll tilt passive, self-motions. Roll tilt thresholds were 31 % higher after ingestion of promethazine ( P  = 0.005). There were no statistically significant changes in yaw rotation and y-translation thresholds. This worsening of precision could have functional implications, e.g., during driving, bicycling, and piloting tasks. Differing results from some past studies of promethazine on the vestibulo-ocular reflex emphasize the need to study motion perception in addition to motor responses.
ISSN:1525-3961
1438-7573
DOI:10.1007/s10162-017-0622-z