The effect of dietary nitrate supplementation on the spatial heterogeneity of quadriceps deoxygenation during heavy‐intensity cycling

This study investigated the influence of dietary inorganic nitrate (NO3−) supplementation on pulmonary O2 uptake (V˙O2) and muscle deoxyhemoglobin/myoglobin (i.e. deoxy [Hb + Mb]) kinetics during submaximal cycling exercise. In a randomized, placebo‐controlled, cross‐over study, eight healthy and ph...

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Bibliographic Details
Published in:Physiological reports 2017-07, Vol.5 (14), p.e13340-n/a
Main Authors: Breese, Brynmor C., Poole, David C., Okushima, Dai, Bailey, Stephen J., Jones, Andrew M., Kondo, Narihiko, Amano, Tatsuro, Koga, Shunsaku
Format: Article
Language:English
Subjects:
Adult
Conductance
Dietary Supplements
Endurance and Performance
Exercise
Gas exchange
Gas Exchange and Transport
Hemoglobins - metabolism
Heterogeneity
Humans
Infrared spectroscopy
Male
Muscle, Skeletal - drug effects
Muscle, Skeletal - metabolism
Muscle, Skeletal - physiology
Muscles
Myoglobin - metabolism
Myoglobins
nitrate supplementation
Nitrates - administration & dosage
Nitrates - pharmacology
Original Research
Oxygen - metabolism
Oxygen Consumption
oxygen delivery
oxygen utilization
Quadriceps muscle
Skeletal Muscle
Spatial heterogeneity
time resolved near‐infrared spectroscopy
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Summary:This study investigated the influence of dietary inorganic nitrate (NO3−) supplementation on pulmonary O2 uptake (V˙O2) and muscle deoxyhemoglobin/myoglobin (i.e. deoxy [Hb + Mb]) kinetics during submaximal cycling exercise. In a randomized, placebo‐controlled, cross‐over study, eight healthy and physically active male subjects completed two step cycle tests at a work rate equivalent to 50% of the difference between the gas exchange threshold and peak V˙O2 over separate 4‐day supplementation periods with NO3−‐rich (BR; providing 8.4 mmol NO3−∙day−1) and NO3−‐depleted (placebo; PLA) beetroot juice. Pulmonary V˙O2 was measured breath‐by‐breath and time‐resolved near‐infrared spectroscopy was utilized to quantify absolute deoxy [Hb + Mb] and total [Hb + Mb] within the rectus femoris, vastus lateralis, and vastus medialis. There were no significant differences (P > 0.05) in the primary deoxy [Hb + Mb] mean response time or amplitude between the PLA and BR trials at each muscle site. BR significantly increased the mean (three‐site) end‐exercise deoxy [Hb + Mb] (PLA: 91 ± 9 vs. BR: 95 ± 12 μmol/L, P 
ISSN:2051-817X
DOI:10.14814/phy2.13340