Prognostic significance of osteopontin in acute myeloid leukemia: A meta-analysis

Osteopontin (OPN) has been investigated in the field of tumor research for several years. However, the prognostic role of OPN overexpression in acute myeloid leukemia (AML) remains controversial. A meta-analysis of four studies, including a total of 492 patients, was performed to determine the assoc...

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Bibliographic Details
Published in:Molecular and clinical oncology 2017-08, Vol.7 (2), p.275-280
Main Authors: Chen, Yong-Bing, Ren, Si-Mei, Li, Si-Dan, Du, Zhongli
Format: Article
Language:English
Subjects:
Acute myelocytic leukemia
Analysis
Care and treatment
Cellular proteins
Development and progression
Gene expression
Genetic aspects
Health aspects
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Summary:Osteopontin (OPN) has been investigated in the field of tumor research for several years. However, the prognostic role of OPN overexpression in acute myeloid leukemia (AML) remains controversial. A meta-analysis of four studies, including a total of 492 patients, was performed to determine the association of OPN with overall survival (OS) in AML patients. The random-effects model of Der Simonian and Laird was used to synthesize data; hazard ratio (HR) with its 95% confidence interval (CI) was used as the effect size estimate. It was observed that serum-based OPN was inversely correlated with OS and the difference was statistically significant (HR=1.83; 95% CI: 1.43-2.35; P
ISSN:2049-9450
2049-9469
DOI:10.3892/mco.2017.1302