Polydopamine Nanoparticles for Combined Chemo- and Photothermal Cancer Therapy

Cancer therapy with two different modalities can enhance treatment efficacy and reduce side effects. This paper describes a new method for combined chemo- and photothermal therapy of cancer using poly dopamine nanoparticles (PDA-NPs), where PDA-NPs serve not only as a photothermal agent with strong...

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Bibliographic Details
Published in:Nanomaterials (Basel, Switzerland) Switzerland), 2017-06, Vol.7 (7), p.160
Main Authors: Zhu, Zhijun, Su, Ming
Format: Article
Language:English
Subjects:
Cancer
Cancer therapies
Catechol
Cisplatin
Dopamine
Energy conversion
Energy conversion efficiency
Michael reaction
Nanoparticles
Near infrared radiation
Photothermal conversion
Physiological effects
Polyethylene glycol
Polyethylenes
Side effects
Therapy
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Summary:Cancer therapy with two different modalities can enhance treatment efficacy and reduce side effects. This paper describes a new method for combined chemo- and photothermal therapy of cancer using poly dopamine nanoparticles (PDA-NPs), where PDA-NPs serve not only as a photothermal agent with strong near infrared absorbance and high energy conversion efficiency, but also as a carrier to deliver cisplatin via interaction between cisplatin and catechol groups on PDA-NPs. Polyethylene glycol (PEG) was introduced through Michael addition reaction to improve the stability of PDA-NPs in physiological condition. A remarkable synergistic therapeutic effect has been achieved compared with respective single treatments. This work suggests that the PDA-based nanoplatform can be a universal scaffold for combined chemo- and photothermal therapy of cancer.
ISSN:2079-4991
2079-4991
DOI:10.3390/nano7070160