Cancer and the microbiota

A host's microbiota may increase, diminish, or have no effect at all on cancer susceptibility. Assigning causal roles in cancer to specific microbes and microbiotas, unraveling host-microbiota interactions with environmental factors in carcinogenesis, and exploiting such knowledge for cancer di...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2015-04, Vol.348 (6230), p.80-86
Main Author: Garrett, Wendy S.
Format: Article
Language:English
Subjects:
Amplification
Cancer
carcinogenesis
Carcinogenesis - immunology
Carcinogens
Diagnosis
environmental factors
Humans
Immunotherapy - methods
Microbiology
Microbiota - immunology
Microorganisms
neoplasms
Neoplasms - immunology
Neoplasms - microbiology
Neoplasms - therapy
REVIEWS
therapeutics
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Summary:A host's microbiota may increase, diminish, or have no effect at all on cancer susceptibility. Assigning causal roles in cancer to specific microbes and microbiotas, unraveling host-microbiota interactions with environmental factors in carcinogenesis, and exploiting such knowledge for cancer diagnosis and treatment are areas of intensive interest. This Review considers how microbes and the microbiota may amplify or mitigate carcinogenesis, responsiveness to cancer therapeutics, and cancer-associated complications.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.aaa4972