miRNAs in Normal and Malignant Hematopoiesis

Lineage specification is primarily regulated at the transcriptional level and lineage-specific transcription factors determine cell fates. MicroRNAs (miRNAs) are 18-24 nucleotide-long non-coding RNAs that post-transcriptionally decrease the translation of target mRNAs and are essential for many cell...

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Bibliographic Details
Published in:International journal of molecular sciences 2017-07, Vol.18 (7), p.1495
Main Authors: Kotaki, Ryutaro, Koyama-Nasu, Ryo, Yamakawa, Natsuko, Kotani, Ai
Format: Article
Language:English
Subjects:
Animals
B-Lymphocytes - metabolism
Hematopoiesis - genetics
Hematopoiesis - physiology
Humans
Leukemia - genetics
Leukemia - metabolism
Lymphoma - genetics
Lymphoma - metabolism
MicroRNAs - genetics
MicroRNAs - metabolism
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Summary:Lineage specification is primarily regulated at the transcriptional level and lineage-specific transcription factors determine cell fates. MicroRNAs (miRNAs) are 18-24 nucleotide-long non-coding RNAs that post-transcriptionally decrease the translation of target mRNAs and are essential for many cellular functions. miRNAs also regulate lineage specification during hematopoiesis. This review highlights the roles of miRNAs in B-cell development and malignancies, and discusses how miRNA expression profiles correlate with disease prognoses and phenotypes. We also discuss the potential for miRNAs as therapeutic targets and diagnostic tools for B-cell malignancies.
ISSN:1422-0067
1422-0067
DOI:10.3390/ijms18071495