Dexmedetomidine Effect on Emergence Agitation and Delirium in Children Undergoing Laparoscopic Hernia Repair: a Preliminary Study

Objective To evaluate the safety and efficacy of dexmedetomidine (Dex) to prevent emergence agitation (EA) and delirium (ED) in children undergoing laparoscopic hernia repair under general anesthesia. Methods 100 children (1–5 years, 10–25 kg) were randomized into four groups: controls (saline) and...

Full description

Saved in:
Bibliographic Details
Published in:Journal of international medical research 2017-06, Vol.45 (3), p.973-983
Main Authors: Sun, Yingying, Li, Yuanhai, Sun, Yajuan, Wang, Xing, Ye, Hongwu, Yuan, Xianren
Format: Article
Language:English
Subjects:
Child, Preschool
Delirium - drug therapy
Dexmedetomidine - therapeutic use
Female
Herniorrhaphy - adverse effects
Humans
Laparoscopy - adverse effects
Male
Psychomotor Agitation - drug therapy
Research Reports
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c434t-54c08e884ce9b5be11d87bb2e9abbd34d4518c9189f273b0d656b9295ea19a913
cites cdi_FETCH-LOGICAL-c434t-54c08e884ce9b5be11d87bb2e9abbd34d4518c9189f273b0d656b9295ea19a913
container_end_page 983
container_issue 3
container_start_page 973
container_title Journal of international medical research
container_volume 45
creator Sun, Yingying
Li, Yuanhai
Sun, Yajuan
Wang, Xing
Ye, Hongwu
Yuan, Xianren
description Objective To evaluate the safety and efficacy of dexmedetomidine (Dex) to prevent emergence agitation (EA) and delirium (ED) in children undergoing laparoscopic hernia repair under general anesthesia. Methods 100 children (1–5 years, 10–25 kg) were randomized into four groups: controls (saline) and intravenous Dex at 0.25, 0.5, and 1.0 µg/kg (D1, D2, D3, respectively). Dex/saline infusion was started following anesthesia. EA and ED were evaluated on a 5-point scale. Results For the C, D1, D2, and D3 groups, respectively, EA frequencies were 45.8%, 30.4%, 12%, 4%; ED frequencies 29.1%, 13%, 4%, 4%; CHIPPS scores 8, 6, 3, 3; sevoflurane doses from 13.2 ± 3.4 (controls) to 9.4 ± 3.5 ml (D3). Intervals until mask removal/spontaneous eye opening were significantly longer for D2 and D3 than controls. PACU stay was longer for D3. Conclusions There was significantly less postoperative EA and pain, with less sevoflurane required, using Dex.
doi_str_mv 10.1177/0300060517699467
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5536412</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_0300060517699467</sage_id><sourcerecordid>1895276436</sourcerecordid><originalsourceid>FETCH-LOGICAL-c434t-54c08e884ce9b5be11d87bb2e9abbd34d4518c9189f273b0d656b9295ea19a913</originalsourceid><addsrcrecordid>eNp1UUtv1DAQthCIbgt3TshHLgE7sZ2YA1K1XVqklUBAz5Yfk9RVYgc7QfTIP8erLRUgcRppvsc8PoReUPKa0rZ9QxpCiCCctkJKJtpHaENZ21R16T9GmwNcHfATdJrzLSGsFrx-ik7qjrWEErJBPy_gxwQOljh55wPgXd-DXXAMeDdBGiBYwOeDX_TiS08Hhy9g9MmvE_YBb2_86BIEfB1cYUcfBrzXs04x2zh7i68gBa_xZ5i1T2-xxp9SkU8-6HSHvyyru3uGnvR6zPD8vp6h6_e7r9urav_x8sP2fF9Z1rCl4sySDrqOWZCGG6DUda0xNUhtjGuYY5x2VtJO9nXbGOIEF0bWkoOmUkvanKF3R995NeViC2FJelRz8lPZRUXt1d9I8DdqiN8V541gtC4Gr-4NUvy2Ql7U5LOFcdQB4ppVGc3rVrBGFCo5Um15RE7QP4yhRB2SU_8mVyQv_1zvQfA7qkKojoSsB1C3cU2hvOv_hr8AwEujBA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1895276436</pqid></control><display><type>article</type><title>Dexmedetomidine Effect on Emergence Agitation and Delirium in Children Undergoing Laparoscopic Hernia Repair: a Preliminary Study</title><source>PubMed Central (Open Access)</source><source>SAGE Open Access</source><creator>Sun, Yingying ; Li, Yuanhai ; Sun, Yajuan ; Wang, Xing ; Ye, Hongwu ; Yuan, Xianren</creator><creatorcontrib>Sun, Yingying ; Li, Yuanhai ; Sun, Yajuan ; Wang, Xing ; Ye, Hongwu ; Yuan, Xianren</creatorcontrib><description>Objective To evaluate the safety and efficacy of dexmedetomidine (Dex) to prevent emergence agitation (EA) and delirium (ED) in children undergoing laparoscopic hernia repair under general anesthesia. Methods 100 children (1–5 years, 10–25 kg) were randomized into four groups: controls (saline) and intravenous Dex at 0.25, 0.5, and 1.0 µg/kg (D1, D2, D3, respectively). Dex/saline infusion was started following anesthesia. EA and ED were evaluated on a 5-point scale. Results For the C, D1, D2, and D3 groups, respectively, EA frequencies were 45.8%, 30.4%, 12%, 4%; ED frequencies 29.1%, 13%, 4%, 4%; CHIPPS scores 8, 6, 3, 3; sevoflurane doses from 13.2 ± 3.4 (controls) to 9.4 ± 3.5 ml (D3). Intervals until mask removal/spontaneous eye opening were significantly longer for D2 and D3 than controls. PACU stay was longer for D3. Conclusions There was significantly less postoperative EA and pain, with less sevoflurane required, using Dex.</description><identifier>ISSN: 0300-0605</identifier><identifier>EISSN: 1473-2300</identifier><identifier>DOI: 10.1177/0300060517699467</identifier><identifier>PMID: 28470100</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Child, Preschool ; Delirium - drug therapy ; Dexmedetomidine - therapeutic use ; Female ; Herniorrhaphy - adverse effects ; Humans ; Laparoscopy - adverse effects ; Male ; Psychomotor Agitation - drug therapy ; Research Reports</subject><ispartof>Journal of international medical research, 2017-06, Vol.45 (3), p.973-983</ispartof><rights>The Author(s) 2017</rights><rights>The Author(s) 2017 2017 SAGE Publications</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-54c08e884ce9b5be11d87bb2e9abbd34d4518c9189f273b0d656b9295ea19a913</citedby><cites>FETCH-LOGICAL-c434t-54c08e884ce9b5be11d87bb2e9abbd34d4518c9189f273b0d656b9295ea19a913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536412/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536412/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,21966,27853,27924,27925,44945,45333,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28470100$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Yingying</creatorcontrib><creatorcontrib>Li, Yuanhai</creatorcontrib><creatorcontrib>Sun, Yajuan</creatorcontrib><creatorcontrib>Wang, Xing</creatorcontrib><creatorcontrib>Ye, Hongwu</creatorcontrib><creatorcontrib>Yuan, Xianren</creatorcontrib><title>Dexmedetomidine Effect on Emergence Agitation and Delirium in Children Undergoing Laparoscopic Hernia Repair: a Preliminary Study</title><title>Journal of international medical research</title><addtitle>J Int Med Res</addtitle><description>Objective To evaluate the safety and efficacy of dexmedetomidine (Dex) to prevent emergence agitation (EA) and delirium (ED) in children undergoing laparoscopic hernia repair under general anesthesia. Methods 100 children (1–5 years, 10–25 kg) were randomized into four groups: controls (saline) and intravenous Dex at 0.25, 0.5, and 1.0 µg/kg (D1, D2, D3, respectively). Dex/saline infusion was started following anesthesia. EA and ED were evaluated on a 5-point scale. Results For the C, D1, D2, and D3 groups, respectively, EA frequencies were 45.8%, 30.4%, 12%, 4%; ED frequencies 29.1%, 13%, 4%, 4%; CHIPPS scores 8, 6, 3, 3; sevoflurane doses from 13.2 ± 3.4 (controls) to 9.4 ± 3.5 ml (D3). Intervals until mask removal/spontaneous eye opening were significantly longer for D2 and D3 than controls. PACU stay was longer for D3. Conclusions There was significantly less postoperative EA and pain, with less sevoflurane required, using Dex.</description><subject>Child, Preschool</subject><subject>Delirium - drug therapy</subject><subject>Dexmedetomidine - therapeutic use</subject><subject>Female</subject><subject>Herniorrhaphy - adverse effects</subject><subject>Humans</subject><subject>Laparoscopy - adverse effects</subject><subject>Male</subject><subject>Psychomotor Agitation - drug therapy</subject><subject>Research Reports</subject><issn>0300-0605</issn><issn>1473-2300</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><recordid>eNp1UUtv1DAQthCIbgt3TshHLgE7sZ2YA1K1XVqklUBAz5Yfk9RVYgc7QfTIP8erLRUgcRppvsc8PoReUPKa0rZ9QxpCiCCctkJKJtpHaENZ21R16T9GmwNcHfATdJrzLSGsFrx-ik7qjrWEErJBPy_gxwQOljh55wPgXd-DXXAMeDdBGiBYwOeDX_TiS08Hhy9g9MmvE_YBb2_86BIEfB1cYUcfBrzXs04x2zh7i68gBa_xZ5i1T2-xxp9SkU8-6HSHvyyru3uGnvR6zPD8vp6h6_e7r9urav_x8sP2fF9Z1rCl4sySDrqOWZCGG6DUda0xNUhtjGuYY5x2VtJO9nXbGOIEF0bWkoOmUkvanKF3R995NeViC2FJelRz8lPZRUXt1d9I8DdqiN8V541gtC4Gr-4NUvy2Ql7U5LOFcdQB4ppVGc3rVrBGFCo5Um15RE7QP4yhRB2SU_8mVyQv_1zvQfA7qkKojoSsB1C3cU2hvOv_hr8AwEujBA</recordid><startdate>20170601</startdate><enddate>20170601</enddate><creator>Sun, Yingying</creator><creator>Li, Yuanhai</creator><creator>Sun, Yajuan</creator><creator>Wang, Xing</creator><creator>Ye, Hongwu</creator><creator>Yuan, Xianren</creator><general>SAGE Publications</general><scope>AFRWT</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170601</creationdate><title>Dexmedetomidine Effect on Emergence Agitation and Delirium in Children Undergoing Laparoscopic Hernia Repair: a Preliminary Study</title><author>Sun, Yingying ; Li, Yuanhai ; Sun, Yajuan ; Wang, Xing ; Ye, Hongwu ; Yuan, Xianren</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-54c08e884ce9b5be11d87bb2e9abbd34d4518c9189f273b0d656b9295ea19a913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Child, Preschool</topic><topic>Delirium - drug therapy</topic><topic>Dexmedetomidine - therapeutic use</topic><topic>Female</topic><topic>Herniorrhaphy - adverse effects</topic><topic>Humans</topic><topic>Laparoscopy - adverse effects</topic><topic>Male</topic><topic>Psychomotor Agitation - drug therapy</topic><topic>Research Reports</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Yingying</creatorcontrib><creatorcontrib>Li, Yuanhai</creatorcontrib><creatorcontrib>Sun, Yajuan</creatorcontrib><creatorcontrib>Wang, Xing</creatorcontrib><creatorcontrib>Ye, Hongwu</creatorcontrib><creatorcontrib>Yuan, Xianren</creatorcontrib><collection>SAGE Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of international medical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Yingying</au><au>Li, Yuanhai</au><au>Sun, Yajuan</au><au>Wang, Xing</au><au>Ye, Hongwu</au><au>Yuan, Xianren</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dexmedetomidine Effect on Emergence Agitation and Delirium in Children Undergoing Laparoscopic Hernia Repair: a Preliminary Study</atitle><jtitle>Journal of international medical research</jtitle><addtitle>J Int Med Res</addtitle><date>2017-06-01</date><risdate>2017</risdate><volume>45</volume><issue>3</issue><spage>973</spage><epage>983</epage><pages>973-983</pages><issn>0300-0605</issn><eissn>1473-2300</eissn><abstract>Objective To evaluate the safety and efficacy of dexmedetomidine (Dex) to prevent emergence agitation (EA) and delirium (ED) in children undergoing laparoscopic hernia repair under general anesthesia. Methods 100 children (1–5 years, 10–25 kg) were randomized into four groups: controls (saline) and intravenous Dex at 0.25, 0.5, and 1.0 µg/kg (D1, D2, D3, respectively). Dex/saline infusion was started following anesthesia. EA and ED were evaluated on a 5-point scale. Results For the C, D1, D2, and D3 groups, respectively, EA frequencies were 45.8%, 30.4%, 12%, 4%; ED frequencies 29.1%, 13%, 4%, 4%; CHIPPS scores 8, 6, 3, 3; sevoflurane doses from 13.2 ± 3.4 (controls) to 9.4 ± 3.5 ml (D3). Intervals until mask removal/spontaneous eye opening were significantly longer for D2 and D3 than controls. PACU stay was longer for D3. Conclusions There was significantly less postoperative EA and pain, with less sevoflurane required, using Dex.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>28470100</pmid><doi>10.1177/0300060517699467</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0300-0605
ispartof Journal of international medical research, 2017-06, Vol.45 (3), p.973-983
issn 0300-0605
1473-2300
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5536412
source PubMed Central (Open Access); SAGE Open Access
subjects Child, Preschool
Delirium - drug therapy
Dexmedetomidine - therapeutic use
Female
Herniorrhaphy - adverse effects
Humans
Laparoscopy - adverse effects
Male
Psychomotor Agitation - drug therapy
Research Reports
title Dexmedetomidine Effect on Emergence Agitation and Delirium in Children Undergoing Laparoscopic Hernia Repair: a Preliminary Study
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T09%3A41%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dexmedetomidine%20Effect%20on%20Emergence%20Agitation%20and%20Delirium%20in%20Children%20Undergoing%20Laparoscopic%20Hernia%20Repair:%20a%20Preliminary%20Study&rft.jtitle=Journal%20of%20international%20medical%20research&rft.au=Sun,%20Yingying&rft.date=2017-06-01&rft.volume=45&rft.issue=3&rft.spage=973&rft.epage=983&rft.pages=973-983&rft.issn=0300-0605&rft.eissn=1473-2300&rft_id=info:doi/10.1177/0300060517699467&rft_dat=%3Cproquest_pubme%3E1895276436%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c434t-54c08e884ce9b5be11d87bb2e9abbd34d4518c9189f273b0d656b9295ea19a913%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1895276436&rft_id=info:pmid/28470100&rft_sage_id=10.1177_0300060517699467&rfr_iscdi=true