Relationship between platelet parameters and hepatic pathology in patients with chronic hepatitis B infection – a retrospective cohort study of 677 patients

Objective A retrospective study to determine the relationships between platelet parameters and inflammation and fibrosis of the liver in patients with chronic hepatitis B virus infection (CHB). Methods Patients with liver biopsy-confirmed CHB were included in the study. Liver fibrosis and inflammati...

Full description

Saved in:
Bibliographic Details
Published in:Journal of international medical research 2016-08, Vol.44 (4), p.779-786
Main Authors: Pan, Ye, Muheremu, Aikeremujiang, Wu, Xiaolu, Liu, Jiajun
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Asian Continental Ancestry Group
Blood Platelets - pathology
Child
Female
Hepatitis B, Chronic - pathology
Humans
Inflammation - pathology
Liver - pathology
Liver Cirrhosis - pathology
Male
Middle Aged
Research Reports
Retrospective Studies
ROC Curve
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective A retrospective study to determine the relationships between platelet parameters and inflammation and fibrosis of the liver in patients with chronic hepatitis B virus infection (CHB). Methods Patients with liver biopsy-confirmed CHB were included in the study. Liver fibrosis and inflammation were assessed by histopathology of biopsied liver tissue. Platelet count (PLT), platelet distribution width (PDW) and mean platelet volume (MPV) were determined as part of routine blood tests. The relationship between inflammation and fibrosis and platelet parameters were analysed by multiple linear regression. Results The study included 677 patients. PLT and PDW accounted for 20.5% of liver inflammation. PLT and PDW accounted for 18.4% of liver fibrosis. Conclusion Platelet parameters can provide valuable information for the assessment of hepatic inflammation and fibrosis.
ISSN:0300-0605
1473-2300
DOI:10.1177/0300060516650076