The role of IL-6 in neurodevelopment after prenatal stress

Highlights • Microglia and maternal IL-6 may be involved in the effects of prenatal stress. . • Prenatal stress effects on embryonic and adult microglia involved prenatal IL-6. . • GABAergic progenitor migration was delayed by prenatal stress and IL-6. • Prenatal stress behaviors did not show a role...

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2017-10, Vol.65, p.274-283
Main Authors: Gumusoglu, Serena B, Fine, Rebecca S, Murray, Samuel J, Bittle, Jada L, Stevens, Hanna E
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Anxiety - immunology
Behavior, Animal - drug effects
Brain - metabolism
Cytokines - metabolism
Disease Models, Animal
Embryonic
Female
Gaba
GABA Agents - pharmacology
GABAergic Neurons - drug effects
IL-6
Interleukin-6 - metabolism
Interleukin-6 - pharmacology
Interleukin-6 - physiology
Male
Mice
Microglia
Microglia - drug effects
Pregnancy
Prenatal Exposure Delayed Effects - immunology
Prenatal stress
Psychiatry
Stress, Psychological - immunology
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Summary:Highlights • Microglia and maternal IL-6 may be involved in the effects of prenatal stress. . • Prenatal stress effects on embryonic and adult microglia involved prenatal IL-6. . • GABAergic progenitor migration was delayed by prenatal stress and IL-6. • Prenatal stress behaviors did not show a role for prenatal IL-6. • Prenatal stress behaviors correlated more with GABAergic changes than with microglia.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2017.05.015