Xfin: an embryonic gene encoding a multifingered protein in Xenopus

The Xenopus laevis genome was screened for putative DNA‐binding gene products by using the ‘finger’ region of the Drosophila gene Krüppel as a probe. The one gene detected, named Xfin, codes for a protein with 37 finger domains that comprise nearly 90% of the protein. In the light of studies by Rhod...

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Bibliographic Details
Published in:The EMBO journal 1987-10, Vol.6 (10), p.3065-3070
Main Authors: Ruiz i Altaba, A., Perry‐O'Keefe, H., Melton, D. A.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Base Sequence
Biological and medical sciences
DNA - analysis
DNA Restriction Enzymes
DNA-Binding Proteins - genetics
Embryo, Nonmammalian - physiology
Fundamental and applied biological sciences. Psychology
Gene expression
Genes
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
RNA, Messenger - genetics
Transcription, Genetic
Xenopus laevis
Xenopus laevis - embryology
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Summary:The Xenopus laevis genome was screened for putative DNA‐binding gene products by using the ‘finger’ region of the Drosophila gene Krüppel as a probe. The one gene detected, named Xfin, codes for a protein with 37 finger domains that comprise nearly 90% of the protein. In the light of studies by Rhodes and Klug (Cell, 46, 123‐132, 1986), these data suggest that the Xfin protein has the capacity to bind an unusually large stretch (185 bases) of DNA. The Xfin gene is expressed as a maternal and zygotic mRNA that undergoes extensive polyadenylation changes during early development. The Xfin mRNA expression pattern and the potential DNA binding activity of the protein point to the possibility that the Xfin gene may have a role in controlling gene activity during early embryonic development.
ISSN:0261-4189
1460-2075
DOI:10.1002/j.1460-2075.1987.tb02613.x