Resistance training improves aortic structure in Wistar rats

• Published in: Revista brasileira de fisioterapia (São Carlos (São Paulo, Brazil)) Brazil)), 2017-07, Vol.21 (4), p.244-250
• Main Authors: Souza, Romeu R., de França, Elias, Madureira, Diana, Pontes, Carla C.R., Santana, Jeferson O., Caperuto, Erico C.
• Format: Article
• Language: English
• Subjects: Anaerobic training; Animals; Blood Pressure - physiology; Great vessels; Heart - physiopathology; Hypertrophy, Left Ventricular - physiopathology; Morphometry; Movement; Original Research; Rats; Rats, Wistar; Resistance Training - methods
• ISSN: 1413-3555; 1809-9246
• DOI: 10.1016/j.bjpt.2017.05.001

•There is aortic adaptation to resistance training in an experimental animal model.•Resistance training promoted left ventricle concentric hypertrophy and improved aortic wall structure by increasing the density of elastic fibers and collagen fibers and increasing the thickness of collagen fibrils.•Resistance training rats displayed aortic remodeling. Little information is available on the effects of resistance training on the aortic wall. This study aimed to quantify the effects of a resistance-training program on blood pressure and aortic wall structural components. Rats (aged three months) were randomized into sedentary group (control group, CG; n=10) or trained group (TG; n=10). The TG rats performed resistance training by climbing a 1.1-m vertical ladder (80° incline) five times a week for 12 weeks, and the CG remained sedentary. The rats were sacrificed and 5mm of the ascending aorta was submitted to histological sections, which were stained with hematoxylin–eosin, Picrosirius red, and Verhoeff's elastin, and used for morphometric studies. Left ventricle (LV) hypertrophy was determined by measuring LV wall thickness and LV internal diameter. The rats had similar repetition maximum before the resistance training. At the end of the resistance training period, the repetition maximum of the TG was 3.04-fold greater than the body weight. In the twelfth month, the left ventricular weight was 15.3% larger in the TG than in the CG, and the left ventricular internal diameter was reduced by 10% in the TG. Rats exposed to resistance training had a significant increase in aortic wall thickness, in both elastic lamina and collagen fibers, and in the thickness of collagen fibrils. Resistance training induces the development of concentric cardiac hypertrophy and improves the aortic wall components by producing a morphological expression pattern distinct from aortic pathological adaptation.