Effect of the recombinant vaccinia viruses that express HTLV‐I envelope gene on HTLV‐I infection

The human T‐lymphotropic virus type I (HTLV‐I) is etiologically linked to adult T‐cell leukemia (ATL). To develop a vaccine against ATL, we constructed recombinant vaccinia viruses containing the envelope gene of HTLV‐I in the vaccinia virus hemagglutinin (HA) gene, a new site where foreign genes ca...

Full description

Saved in:
Bibliographic Details
Published in:The EMBO journal 1987-11, Vol.6 (11), p.3379-3384
Main Authors: Shida, H., Tochikura, T., Sato, T., Konno, T., Hirayoshi, K., Seki, M., Ito, Y., Hatanaka, M., Hinuma, Y., Sugimoto, M.
Format: Article
Language:English
Subjects:
Animals
Antigens, Viral - analysis
Antigens, Viral - genetics
Biological and medical sciences
Cell Line
Deltaretrovirus - genetics
Fundamental and applied biological sciences. Psychology
Genes
Genes, Viral
Genetic Vectors
Microbiology
Plasmids
Promoter Regions, Genetic
Rabbits
Recombination, Genetic
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
Vaccinia virus - genetics
Viral Envelope Proteins - genetics
Virology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The human T‐lymphotropic virus type I (HTLV‐I) is etiologically linked to adult T‐cell leukemia (ATL). To develop a vaccine against ATL, we constructed recombinant vaccinia viruses containing the envelope gene of HTLV‐I in the vaccinia virus hemagglutinin (HA) gene, a new site where foreign genes can be inserted. A single inoculation of the recombinant virus induced antibodies to the env proteins of HTLV‐I in rabbits and had a protective effect against HTLV‐I infection.
ISSN:0261-4189
1460-2075
DOI:10.1002/j.1460-2075.1987.tb02660.x