Unique prefrontal GABA and glutamate disturbances in co-occurring bipolar disorder and alcohol dependence

Bipolar disorder (BD) and alcohol dependence (AD) frequently co-occur, and co-occurring BD and AD are associated with devastating public health costs. Minimal neurobiological research exists to guide the development of effective treatments for this treatment-resistant population. We believe the pres...

Full description

Saved in:
Bibliographic Details
Published in:Translational psychiatry 2017-07, Vol.7 (7), p.e1163-e1163
Main Authors: Prisciandaro, J J, Tolliver, B K, Prescot, A P, Brenner, H M, Renshaw, P F, Brown, T R, Anton, R F
Format: Article
Language:English
Subjects:
59/57
692/699/476/1333
692/699/476/5
Adult
Alcohol
Alcoholism - complications
Alcoholism - metabolism
Alcoholism - psychology
Behavioral Sciences
Biological Psychology
Bipolar disorder
Bipolar Disorder - complications
Bipolar Disorder - metabolism
Bipolar Disorder - psychology
Craving
Female
gamma-Aminobutyric Acid - metabolism
Glutamic Acid - metabolism
Gyrus Cinguli - metabolism
Humans
Impulsive Behavior
Male
Medicine
Medicine & Public Health
Middle Aged
Neurosciences
Original
original-article
Pharmacotherapy
Prefrontal Cortex - metabolism
Proton Magnetic Resonance Spectroscopy
Psychiatry
Water levels
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Bipolar disorder (BD) and alcohol dependence (AD) frequently co-occur, and co-occurring BD and AD are associated with devastating public health costs. Minimal neurobiological research exists to guide the development of effective treatments for this treatment-resistant population. We believe the present study represents the first investigation of prefrontal gamma-aminobutyric acid (GABA) and glutamate levels in co-occurring BD and current AD. The participants were 78 individuals who met DSM-IV criteria for BD I/II and current AD ( n =20), BD I/II alone ( n =19), current AD alone ( n =20) or no diagnosis ( n =19). The participants completed a baseline diagnostic visit, then returned approximately 4 days later for a two-dimensional J-resolved proton magnetic resonance spectroscopy ( 1 H-MRS) acquisition in dorsal anterior cingulate cortex (dACC). All participants were required to demonstrate ⩾1 week of abstinence from alcohol/drugs via serial biomarker testing before 1 H-MRS. A 2 × 2 factorial analysis of variance of cerebrospinal fluid (CSF)-corrected GABA/water concentrations demonstrated a significant BD × AD interaction (F=2.91, P
ISSN:2158-3188
2158-3188
DOI:10.1038/tp.2017.141