Angiogenesis Dysregulation in Psoriatic Arthritis: Molecular Mechanisms

There is evidence that psoriatic arthritis is closely linked to angiogenesis. Morphological changes described in blood vessels of psoriatic arthritis joints suggest the presence of a dysregulated angiogenesis resulting in the formation of immature vessels. Even if the reason of this inefficient angi...

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Bibliographic Details
Published in:BioMed research international 2017-01, Vol.2017 (2017), p.1-6
Main Authors: Ribatti, Domenico, Corrado, Addolorata, Maruotti, Nicola, Cantatore, Francesco Paolo
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
Antiangiogenics
Arthritis
Arthritis, Psoriatic - metabolism
Arthritis, Psoriatic - pathology
Arthritis, Psoriatic - physiopathology
Autoimmune diseases
Blood vessels
Chemokines
Cytokines
Enzymes
Humans
Hypoxia
Joint diseases
Magnetic resonance imaging
Molecular modelling
Morphology
Neovascularization
Neovascularization, Pathologic - metabolism
Neovascularization, Pathologic - pathology
Neovascularization, Pathologic - physiopathology
Pathogenesis
Psoriasis
Psoriatic arthritis
Review
Rheumatism
Rheumatoid arthritis
Tumor necrosis factor-TNF
Vascular endothelial growth factor
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Summary:There is evidence that psoriatic arthritis is closely linked to angiogenesis. Morphological changes described in blood vessels of psoriatic arthritis joints suggest the presence of a dysregulated angiogenesis resulting in the formation of immature vessels. Even if the reason of this inefficient angiogenesis is still unclear, an imbalance between angiogenic and antiangiogenic factors is probably responsible for inducing a dysregulated angiogenesis in psoriatic arthritis, which seems to be involved in its pathogenesis and clinical features. Nevertheless, among chronic arthritides, while angiogenesis in rheumatoid arthritis has been largely studied with a great amount of literature data, limited data on angiogenesis role in psoriatic arthritis are available. This review article is focused on current knowledge on the mechanisms responsible for dysregulated angiogenesis in psoriatic arthritis.
ISSN:2314-6133
2314-6141
DOI:10.1155/2017/5312813