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Cervical Infection with Cutaneous Beta and Mucosal Alpha Papillomaviruses
Alpha-human papillomavirus (α-HPV) plays a causal role in cervical cancer, but little is known about the epidemiology of genital Beta-human papillomavirus (β-HPV) infection. We used Luminex and PCR hybridization to detect β- and α-HPVs prevalence at enrollment and 12-month follow-up in cervical samp...
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Published in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2017-08, Vol.26 (8), p.1312-1320 |
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description | Alpha-human papillomavirus (α-HPV) plays a causal role in cervical cancer, but little is known about the epidemiology of genital Beta-human papillomavirus (β-HPV) infection.
We used Luminex and PCR hybridization to detect β- and α-HPVs prevalence at enrollment and 12-month follow-up in cervical samples from 505 women enrolled in the Ludwig-McGill cohort study. We compared epidemiologic correlates of both β- and α-HPVs and compared genotypes between these genera with respect to co-occurrence and association with cervical cytologic abnormalities.
Infection with β-HPV types was more prevalent than that with α-HPV types at both visits (cumulative prevalences: 27.3% vs. 21.6%, respectively,
= 0.034). β-HPVs were mostly transient; however, only 1.98% women retained their original positivity at 12 months, whereas persistence was higher for α-HPVs (5.15%;
= 0.007). Age, parity, and sexual activity variables were predictors of α-HPV but not of β-HPV. α- and β-HPV types occurred independently. Increased risk of cervical abnormalities was restricted to women infected with α-9 or α-6 HPV types. We found no epidemiologic correlates for β-HPV infections.
Detection of β-HPV types in the cervix tends to occur as random and transient episodes not explained via the sexual-transmission correlates that characterize infections by α-HPVs.
Although it is plausible that β-HPVs may play a direct or indirect carcinogenic role, the lack of epidemiologic correlates for detection episodes of these viruses and lack of association with cervical lesions speak against their ancillary role as sexually transmitted agents in cervical carcinogenesis.
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doi_str_mv | 10.1158/1055-9965.EPI-17-0081 |
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We used Luminex and PCR hybridization to detect β- and α-HPVs prevalence at enrollment and 12-month follow-up in cervical samples from 505 women enrolled in the Ludwig-McGill cohort study. We compared epidemiologic correlates of both β- and α-HPVs and compared genotypes between these genera with respect to co-occurrence and association with cervical cytologic abnormalities.
Infection with β-HPV types was more prevalent than that with α-HPV types at both visits (cumulative prevalences: 27.3% vs. 21.6%, respectively,
= 0.034). β-HPVs were mostly transient; however, only 1.98% women retained their original positivity at 12 months, whereas persistence was higher for α-HPVs (5.15%;
= 0.007). Age, parity, and sexual activity variables were predictors of α-HPV but not of β-HPV. α- and β-HPV types occurred independently. Increased risk of cervical abnormalities was restricted to women infected with α-9 or α-6 HPV types. We found no epidemiologic correlates for β-HPV infections.
Detection of β-HPV types in the cervix tends to occur as random and transient episodes not explained via the sexual-transmission correlates that characterize infections by α-HPVs.
Although it is plausible that β-HPVs may play a direct or indirect carcinogenic role, the lack of epidemiologic correlates for detection episodes of these viruses and lack of association with cervical lesions speak against their ancillary role as sexually transmitted agents in cervical carcinogenesis.
.</description><identifier>ISSN: 1055-9965</identifier><identifier>EISSN: 1538-7755</identifier><identifier>DOI: 10.1158/1055-9965.EPI-17-0081</identifier><identifier>PMID: 28377417</identifier><language>eng</language><publisher>United States: American Association for Cancer Research, Inc</publisher><subject>Adolescent ; Adult ; Alphapapillomavirus - pathogenicity ; Betapapillomavirus - pathogenicity ; Carcinogenesis ; Cervical cancer ; Cervix Uteri - pathology ; Cohort Studies ; Disease transmission ; Epidemiology ; Female ; Genotype ; Genotypes ; Human papillomavirus ; Humans ; Hybridization ; Infections ; Lesions ; Longitudinal Studies ; Middle Aged ; Mucosa ; Papillomaviridae ; Papillomaviridae - genetics ; Risk Factors ; Sexual transmission ; Uterine Cervical Neoplasms - virology ; Vaccines ; Viruses ; Young Adult</subject><ispartof>Cancer epidemiology, biomarkers & prevention, 2017-08, Vol.26 (8), p.1312-1320</ispartof><rights>2017 American Association for Cancer Research.</rights><rights>Copyright American Association for Cancer Research, Inc. Aug 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-b6d1deac4119e75d81b6794e70becd23fe7e0603acbfaf71a62aaf8a70e5bda73</citedby><cites>FETCH-LOGICAL-c439t-b6d1deac4119e75d81b6794e70becd23fe7e0603acbfaf71a62aaf8a70e5bda73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28377417$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sichero, Laura</creatorcontrib><creatorcontrib>El-Zein, Mariam</creatorcontrib><creatorcontrib>Nunes, Emily M</creatorcontrib><creatorcontrib>Ferreira, Silvaneide</creatorcontrib><creatorcontrib>Franco, Eduardo L</creatorcontrib><creatorcontrib>Villa, Luisa L</creatorcontrib><creatorcontrib>Ludwig-McGill Cohort Study</creatorcontrib><title>Cervical Infection with Cutaneous Beta and Mucosal Alpha Papillomaviruses</title><title>Cancer epidemiology, biomarkers & prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>Alpha-human papillomavirus (α-HPV) plays a causal role in cervical cancer, but little is known about the epidemiology of genital Beta-human papillomavirus (β-HPV) infection.
We used Luminex and PCR hybridization to detect β- and α-HPVs prevalence at enrollment and 12-month follow-up in cervical samples from 505 women enrolled in the Ludwig-McGill cohort study. We compared epidemiologic correlates of both β- and α-HPVs and compared genotypes between these genera with respect to co-occurrence and association with cervical cytologic abnormalities.
Infection with β-HPV types was more prevalent than that with α-HPV types at both visits (cumulative prevalences: 27.3% vs. 21.6%, respectively,
= 0.034). β-HPVs were mostly transient; however, only 1.98% women retained their original positivity at 12 months, whereas persistence was higher for α-HPVs (5.15%;
= 0.007). Age, parity, and sexual activity variables were predictors of α-HPV but not of β-HPV. α- and β-HPV types occurred independently. Increased risk of cervical abnormalities was restricted to women infected with α-9 or α-6 HPV types. We found no epidemiologic correlates for β-HPV infections.
Detection of β-HPV types in the cervix tends to occur as random and transient episodes not explained via the sexual-transmission correlates that characterize infections by α-HPVs.
Although it is plausible that β-HPVs may play a direct or indirect carcinogenic role, the lack of epidemiologic correlates for detection episodes of these viruses and lack of association with cervical lesions speak against their ancillary role as sexually transmitted agents in cervical carcinogenesis.
.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Alphapapillomavirus - pathogenicity</subject><subject>Betapapillomavirus - pathogenicity</subject><subject>Carcinogenesis</subject><subject>Cervical cancer</subject><subject>Cervix Uteri - pathology</subject><subject>Cohort Studies</subject><subject>Disease transmission</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Genotype</subject><subject>Genotypes</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>Hybridization</subject><subject>Infections</subject><subject>Lesions</subject><subject>Longitudinal Studies</subject><subject>Middle Aged</subject><subject>Mucosa</subject><subject>Papillomaviridae</subject><subject>Papillomaviridae - genetics</subject><subject>Risk Factors</subject><subject>Sexual transmission</subject><subject>Uterine Cervical Neoplasms - virology</subject><subject>Vaccines</subject><subject>Viruses</subject><subject>Young Adult</subject><issn>1055-9965</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNpdkcFq3DAQhkVJaJJtH6HFkEsv3mgsy5Ivhc2ySRa2NIf2LMbyuKvgtbaSvSVvH5tNQpOTBvTNz_x8jH0BPgeQ-gq4lGlZFnK-ul-noFLONXxg5yCFTpWS8mScX5gzdhHjA-dclVJ-ZGeZFkrloM7Zeknh4Cy2ybpryPbOd8k_12-T5dBjR36IyTX1mGBXJz8G6-NILtr9FpN73Lu29Ts8uDBEip_YaYNtpM_P74z9vln9Wt6lm5-36-Vik9pclH1aFTXUhDYHKEnJWkNVqDInxSuydSYaUsQLLtBWDTYKsMgQG42Kk6xqVGLGvh9z90O1o9pS1wdszT64HYZH49GZtz-d25o__mCkzLmS2Rjw7Tkg-L8Dxd7sXLTUtse-BrTO80LknI_o5Tv0wQ-hG-sZKLXIZJYVU6A8Ujb4GAM1r8cAN5MsM4kwkwgzyjKgzCRr3Pv6f5PXrRc74gm13ZII</recordid><startdate>20170801</startdate><enddate>20170801</enddate><creator>Sichero, Laura</creator><creator>El-Zein, Mariam</creator><creator>Nunes, Emily M</creator><creator>Ferreira, Silvaneide</creator><creator>Franco, Eduardo L</creator><creator>Villa, Luisa L</creator><general>American Association for Cancer Research, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170801</creationdate><title>Cervical Infection with Cutaneous Beta and Mucosal Alpha Papillomaviruses</title><author>Sichero, Laura ; El-Zein, Mariam ; Nunes, Emily M ; Ferreira, Silvaneide ; Franco, Eduardo L ; Villa, Luisa L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-b6d1deac4119e75d81b6794e70becd23fe7e0603acbfaf71a62aaf8a70e5bda73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Alphapapillomavirus - pathogenicity</topic><topic>Betapapillomavirus - pathogenicity</topic><topic>Carcinogenesis</topic><topic>Cervical cancer</topic><topic>Cervix Uteri - pathology</topic><topic>Cohort Studies</topic><topic>Disease transmission</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Genotype</topic><topic>Genotypes</topic><topic>Human papillomavirus</topic><topic>Humans</topic><topic>Hybridization</topic><topic>Infections</topic><topic>Lesions</topic><topic>Longitudinal Studies</topic><topic>Middle Aged</topic><topic>Mucosa</topic><topic>Papillomaviridae</topic><topic>Papillomaviridae - genetics</topic><topic>Risk Factors</topic><topic>Sexual transmission</topic><topic>Uterine Cervical Neoplasms - virology</topic><topic>Vaccines</topic><topic>Viruses</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sichero, Laura</creatorcontrib><creatorcontrib>El-Zein, Mariam</creatorcontrib><creatorcontrib>Nunes, Emily M</creatorcontrib><creatorcontrib>Ferreira, Silvaneide</creatorcontrib><creatorcontrib>Franco, Eduardo L</creatorcontrib><creatorcontrib>Villa, Luisa L</creatorcontrib><creatorcontrib>Ludwig-McGill Cohort Study</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sichero, Laura</au><au>El-Zein, Mariam</au><au>Nunes, Emily M</au><au>Ferreira, Silvaneide</au><au>Franco, Eduardo L</au><au>Villa, Luisa L</au><aucorp>Ludwig-McGill Cohort Study</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cervical Infection with Cutaneous Beta and Mucosal Alpha Papillomaviruses</atitle><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><date>2017-08-01</date><risdate>2017</risdate><volume>26</volume><issue>8</issue><spage>1312</spage><epage>1320</epage><pages>1312-1320</pages><issn>1055-9965</issn><eissn>1538-7755</eissn><abstract>Alpha-human papillomavirus (α-HPV) plays a causal role in cervical cancer, but little is known about the epidemiology of genital Beta-human papillomavirus (β-HPV) infection.
We used Luminex and PCR hybridization to detect β- and α-HPVs prevalence at enrollment and 12-month follow-up in cervical samples from 505 women enrolled in the Ludwig-McGill cohort study. We compared epidemiologic correlates of both β- and α-HPVs and compared genotypes between these genera with respect to co-occurrence and association with cervical cytologic abnormalities.
Infection with β-HPV types was more prevalent than that with α-HPV types at both visits (cumulative prevalences: 27.3% vs. 21.6%, respectively,
= 0.034). β-HPVs were mostly transient; however, only 1.98% women retained their original positivity at 12 months, whereas persistence was higher for α-HPVs (5.15%;
= 0.007). Age, parity, and sexual activity variables were predictors of α-HPV but not of β-HPV. α- and β-HPV types occurred independently. Increased risk of cervical abnormalities was restricted to women infected with α-9 or α-6 HPV types. We found no epidemiologic correlates for β-HPV infections.
Detection of β-HPV types in the cervix tends to occur as random and transient episodes not explained via the sexual-transmission correlates that characterize infections by α-HPVs.
Although it is plausible that β-HPVs may play a direct or indirect carcinogenic role, the lack of epidemiologic correlates for detection episodes of these viruses and lack of association with cervical lesions speak against their ancillary role as sexually transmitted agents in cervical carcinogenesis.
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subjects | Adolescent Adult Alphapapillomavirus - pathogenicity Betapapillomavirus - pathogenicity Carcinogenesis Cervical cancer Cervix Uteri - pathology Cohort Studies Disease transmission Epidemiology Female Genotype Genotypes Human papillomavirus Humans Hybridization Infections Lesions Longitudinal Studies Middle Aged Mucosa Papillomaviridae Papillomaviridae - genetics Risk Factors Sexual transmission Uterine Cervical Neoplasms - virology Vaccines Viruses Young Adult |
title | Cervical Infection with Cutaneous Beta and Mucosal Alpha Papillomaviruses |
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