Associations of B cell‐activating factor (BAFF) and anti‐BAFF autoantibodies with disease activity in multi‐ethnic Asian systemic lupus erythematosus patients in Singapore

Summary To measure the levels of B cell‐activating factor (BAFF) and endogenous anti‐BAFF autoantibodies in a cohort of multi‐ethnic Asian systemic lupus erythematosus (SLE) patients in Singapore, to determine their correlation with disease activity. Serum samples from 121 SLE patients and 24 age‐ a...

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Bibliographic Details
Published in:Clinical and experimental immunology 2017-09, Vol.189 (3), p.298-303
Main Authors: Howe, H. S., Thong, B. Y. H., Kong, K. O., Chng, H. H., Lian, T. Y., Chia, F. L., Tay, K. S. S., Lau, T. C., Law, W. G., Koh, E. T., Leung, B. P.
Format: Article
Language:English
Subjects:
Adult
Anti-DNA antibodies
Antibodies
anti‐BAFF
Asian Continental Ancestry Group
Autoantibodies
Autoantibodies - blood
Autoantibodies - immunology
Autoimmune diseases
B-Cell Activating Factor - blood
B-Cell Activating Factor - immunology
BAFF
BLyS protein
Chronic conditions
Clinical trials
Cytokines
Enzyme-Linked Immunosorbent Assay
Female
Health risk assessment
Humans
IgG antibody
Immunoglobulin G
Immunoglobulin G - blood
Immunoglobulin G - immunology
Limit of Detection
Lupus
Lupus Erythematosus, Systemic - blood
Lupus Erythematosus, Systemic - ethnology
Lupus Erythematosus, Systemic - immunology
Lupus Erythematosus, Systemic - physiopathology
Lymphocytes B
Male
Middle Aged
Original
Singapore - epidemiology
Standard error
Systemic lupus erythematosus
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Summary:Summary To measure the levels of B cell‐activating factor (BAFF) and endogenous anti‐BAFF autoantibodies in a cohort of multi‐ethnic Asian systemic lupus erythematosus (SLE) patients in Singapore, to determine their correlation with disease activity. Serum samples from 121 SLE patients and 24 age‐ and sex‐matched healthy controls were assayed for BAFF and anti‐BAFF immunoglobulin (Ig)G antibody levels by enzyme‐linked immunosorbent assay (ELISA). The lowest reliable detection limit for anti‐BAFF‐IgG antibody levels was defined as 2 standard deviations (s.d.) from blank. Correlation of serum BAFF and anti‐BAFF IgG levels with disease activity [scored by SLE Activity Measure revised (SLAM‐R)], and disease manifestations were determined in these 121 patients. SLE patients had elevated BAFF levels compared to controls; mean 820 ± 40 pg/ml and 152 pg ± 45/ml, respectively [mean ± standard error of the mean (s.e.m.), P 
ISSN:0009-9104
1365-2249
DOI:10.1111/cei.12975