Congenital Hypotransferrinemia, an Unusual Cause of Iron Deficiency Anemia: Report of Two Cases

Hereditary hypotransferrinemia is a very rare cause of iron deficiency anemia in childhood characterized by microcytic hypochromic anemia refractory to iron therapy and concomitant iron overload. Regular plasma infusion to replace the deficient transferrin molecule is the therapeutic option. We repo...

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Bibliographic Details
Published in:Indian journal of hematology & blood transfusion 2017-09, Vol.33 (3), p.402-404
Main Authors: Chandra, Dinesh, Dhingra, Bhavna, Seth, Tulika, Mishra, Pravas, Bansal, Divya, Mahapatra, Manoranjan, Pati, H. P.
Format: Article
Language:English
Subjects:
Anemia
Blood diseases
Blood Transfusion Medicine
Blood transfusions
Congenital diseases
Hematology
Human Genetics
Iron
Medicine
Medicine & Public Health
Oncology
Short Communication
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Summary:Hereditary hypotransferrinemia is a very rare cause of iron deficiency anemia in childhood characterized by microcytic hypochromic anemia refractory to iron therapy and concomitant iron overload. Regular plasma infusion to replace the deficient transferrin molecule is the therapeutic option. We report two cases; both presented with refractory anemia requiring blood transfusions and responded to monthly fresh frozen plasma replacement.
ISSN:0971-4502
0974-0449
0974-0449
0971-4502
DOI:10.1007/s12288-016-0746-z