Genomic alterations as predictors of survival among patients within a combined cohort with clear cell renal cell carcinoma undergoing cytoreductive nephrectomy

Abstract Purpose To establish prognostic genomic biomarkers for patients with metastatic clear cell renal cell carcinoma (ccRCC). Materials and methods We identified 60 patients who presented with metastatic ccRCC at our institution between 2001 and 2015 and had genomic sequencing on their primary t...

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Bibliographic Details
Published in:Urologic oncology 2017-08, Vol.35 (8), p.532.e7-532.e13
Main Authors: Tennenbaum, Daniel M., BA, Manley, Brandon J., MD, Zabor, Emily, MS, Becerra, Maria F., MD, Carlo, Maria I., MD, Casuscelli, Jozefina, MD, Redzematovic, Almedina, MS, Khan, Nabeela, MD, Arcila, Maria E., MD, Voss, Martin H., MD, Feldman, Darren R., MD, Motzer, Robert J., MD, Benfante, Nicole E., BA, Coleman, Jonathan A., MD, Russo, Paul, MD, Hsieh, James J., MD, PhD, Hakimi, Abraham Ari, MD
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor - genetics
Carcinoma, Renal Cell - genetics
Carcinoma, Renal Cell - mortality
Carcinoma, Renal Cell - surgery
Cohort Studies
Cytoreduction Surgical Procedures
DNA Mutational Analysis
Female
Genomics
Histone Demethylases - genetics
Histone-Lysine N-Methyltransferase - genetics
Humans
Kaplan-Meier Estimate
Kidney Neoplasms - genetics
Kidney Neoplasms - mortality
Kidney Neoplasms - surgery
Male
Middle Aged
Mortality
Mutation
Neoplasm metastasis
Nephrectomy
Prognosis
Renal cell carcinoma
Tumor Suppressor Proteins - genetics
Ubiquitin Thiolesterase - genetics
Urology
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Summary:Abstract Purpose To establish prognostic genomic biomarkers for patients with metastatic clear cell renal cell carcinoma (ccRCC). Materials and methods We identified 60 patients who presented with metastatic ccRCC at our institution between 2001 and 2015 and had genomic sequencing on their primary tumor. We pooled these patients with 107 other patients with the same inclusion criteria from three well-known public databases. Five commonly mutated genes were chosen for analysis: VHL , PBRM1 , BAP1 , SETD2 , and KDM5C . Overall survival (OS) was estimated using the Kaplan-Meier method and the log-rank test was used for comparisons between groups. Results Median OS in the cohort was 2.5 years. Higher Fuhrman grade was associated with decreased median OS ( P
ISSN:1078-1439
1873-2496
DOI:10.1016/j.urolonc.2017.03.015