Peripheral zinc and neopterin concentrations are associated with mood severity in bipolar disorder in a gender-specific manner

Abstract Bipolar disorder (BD) is a recurrent, episodic mood disorder for which there are no current diagnostic, prognostic or theranostic biomarkers. Two peripheral markers of the acute phase immune response, zinc and neopterin, are consistently associated with severity of depression in literature....

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Bibliographic Details
Published in:Psychiatry research 2017-09, Vol.255, p.52-58
Main Authors: Millett, Caitlin E, Mukherjee, Dahlia, Reider, Aubrey, Can, Adem, Groer, Maureen, Fuchs, Dietmar, Postolache, Teodor T, Kelleher, Shannon L, Saunders, Erika F.H
Format: Article
Language:English
Subjects:
Adult
Affect - physiology
Biological marker
Biomarkers - blood
Bipolar depression
Bipolar Disorder - blood
Bipolar Disorder - psychology
Female
Gender
Humans
Inflammation
Male
Neopterin - blood
Psychiatry
Severity of Illness Index
Sex Factors
Zinc
Zinc - blood
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Summary:Abstract Bipolar disorder (BD) is a recurrent, episodic mood disorder for which there are no current diagnostic, prognostic or theranostic biomarkers. Two peripheral markers of the acute phase immune response, zinc and neopterin, are consistently associated with severity of depression in literature. Given gender differences in clinical presentation of BD and in inflammatory processes, we aimed to explore the interaction between gender and immune biomarkers to predict mood severity in BD. Participants with DSM IV BD I and II were recruited through the Pennsylvania Psychiatric Institute during an acute mood episode. Healthy controls (HC) were recruited through advertisements. Participants fasted for at least 6 h when blood was drawn for biomarkers. We found that zinc concentrations were significantly lower in the BD group at baseline (p
ISSN:0165-1781
1872-7123
DOI:10.1016/j.psychres.2017.05.022