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Peripheral zinc and neopterin concentrations are associated with mood severity in bipolar disorder in a gender-specific manner
Abstract Bipolar disorder (BD) is a recurrent, episodic mood disorder for which there are no current diagnostic, prognostic or theranostic biomarkers. Two peripheral markers of the acute phase immune response, zinc and neopterin, are consistently associated with severity of depression in literature....
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| Published in: | Psychiatry research 2017-09, Vol.255, p.52-58 |
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| container_title | Psychiatry research |
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| creator | Millett, Caitlin E Mukherjee, Dahlia Reider, Aubrey Can, Adem Groer, Maureen Fuchs, Dietmar Postolache, Teodor T Kelleher, Shannon L Saunders, Erika F.H |
| description | Abstract Bipolar disorder (BD) is a recurrent, episodic mood disorder for which there are no current diagnostic, prognostic or theranostic biomarkers. Two peripheral markers of the acute phase immune response, zinc and neopterin, are consistently associated with severity of depression in literature. Given gender differences in clinical presentation of BD and in inflammatory processes, we aimed to explore the interaction between gender and immune biomarkers to predict mood severity in BD. Participants with DSM IV BD I and II were recruited through the Pennsylvania Psychiatric Institute during an acute mood episode. Healthy controls (HC) were recruited through advertisements. Participants fasted for at least 6 h when blood was drawn for biomarkers. We found that zinc concentrations were significantly lower in the BD group at baseline (p |
| doi_str_mv | 10.1016/j.psychres.2017.05.022 |
| format | article |
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Two peripheral markers of the acute phase immune response, zinc and neopterin, are consistently associated with severity of depression in literature. Given gender differences in clinical presentation of BD and in inflammatory processes, we aimed to explore the interaction between gender and immune biomarkers to predict mood severity in BD. Participants with DSM IV BD I and II were recruited through the Pennsylvania Psychiatric Institute during an acute mood episode. Healthy controls (HC) were recruited through advertisements. Participants fasted for at least 6 h when blood was drawn for biomarkers. We found that zinc concentrations were significantly lower in the BD group at baseline (p<.05), and there was also a significant interaction between gender and zinc (p<.05), associated with depression severity. Also, we found a significant interaction between gender and neopterin, associated with mania severity (p<.05). We found that mania severity was associated with neopterin in men, while depression severity was positively associated with zinc in women. Our report bears replication in larger samples and highlights the potential for differences in the underlying pathophysiology between men and women with BD.</description><identifier>ISSN: 0165-1781</identifier><identifier>EISSN: 1872-7123</identifier><identifier>DOI: 10.1016/j.psychres.2017.05.022</identifier><identifier>PMID: 28528241</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Adult ; Affect - physiology ; Biological marker ; Biomarkers - blood ; Bipolar depression ; Bipolar Disorder - blood ; Bipolar Disorder - psychology ; Female ; Gender ; Humans ; Inflammation ; Male ; Neopterin - blood ; Psychiatry ; Severity of Illness Index ; Sex Factors ; Zinc ; Zinc - blood</subject><ispartof>Psychiatry research, 2017-09, Vol.255, p.52-58</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2017 Elsevier B.V.</rights><rights>Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-36581b01cdd07e0a128308de34adabc4e64d19c4cc63b8b5b10fcea7db71273b3</citedby><cites>FETCH-LOGICAL-c526t-36581b01cdd07e0a128308de34adabc4e64d19c4cc63b8b5b10fcea7db71273b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28528241$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Millett, Caitlin E</creatorcontrib><creatorcontrib>Mukherjee, Dahlia</creatorcontrib><creatorcontrib>Reider, Aubrey</creatorcontrib><creatorcontrib>Can, Adem</creatorcontrib><creatorcontrib>Groer, Maureen</creatorcontrib><creatorcontrib>Fuchs, Dietmar</creatorcontrib><creatorcontrib>Postolache, Teodor T</creatorcontrib><creatorcontrib>Kelleher, Shannon L</creatorcontrib><creatorcontrib>Saunders, Erika F.H</creatorcontrib><title>Peripheral zinc and neopterin concentrations are associated with mood severity in bipolar disorder in a gender-specific manner</title><title>Psychiatry research</title><addtitle>Psychiatry Res</addtitle><description>Abstract Bipolar disorder (BD) is a recurrent, episodic mood disorder for which there are no current diagnostic, prognostic or theranostic biomarkers. Two peripheral markers of the acute phase immune response, zinc and neopterin, are consistently associated with severity of depression in literature. Given gender differences in clinical presentation of BD and in inflammatory processes, we aimed to explore the interaction between gender and immune biomarkers to predict mood severity in BD. Participants with DSM IV BD I and II were recruited through the Pennsylvania Psychiatric Institute during an acute mood episode. Healthy controls (HC) were recruited through advertisements. Participants fasted for at least 6 h when blood was drawn for biomarkers. We found that zinc concentrations were significantly lower in the BD group at baseline (p<.05), and there was also a significant interaction between gender and zinc (p<.05), associated with depression severity. Also, we found a significant interaction between gender and neopterin, associated with mania severity (p<.05). We found that mania severity was associated with neopterin in men, while depression severity was positively associated with zinc in women. Our report bears replication in larger samples and highlights the potential for differences in the underlying pathophysiology between men and women with BD.</description><subject>Adult</subject><subject>Affect - physiology</subject><subject>Biological marker</subject><subject>Biomarkers - blood</subject><subject>Bipolar depression</subject><subject>Bipolar Disorder - blood</subject><subject>Bipolar Disorder - psychology</subject><subject>Female</subject><subject>Gender</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Male</subject><subject>Neopterin - blood</subject><subject>Psychiatry</subject><subject>Severity of Illness Index</subject><subject>Sex Factors</subject><subject>Zinc</subject><subject>Zinc - blood</subject><issn>0165-1781</issn><issn>1872-7123</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqFkk1v1DAQhi0EokvhL1Q-cknw2HHivVSgqnxIlUACzpZjz3a9JHaws4uWA78dR9tWwIWTrfE774znGUIugNXAoH21q6d8tNuEueYMuprJmnH-iKxAdbzqgIvHZFWEsoJOwRl5lvOOMcZhvX5KzriSXPEGVuTXJ0x-2mIyA_3pg6UmOBowTnOJB2pjsBjmZGYfQ6YmITU5R-vNjI7-8POWjjE6mvFQ9PORlpzeT3EwiTqfY3KYlpihtxjKvcoTWr_xlo4mBEzPyZONGTK-uDvPyde311-u3lc3H999uHpzU1nJ27kSrVTQM7DOsQ6ZAa4EUw5FY5zpbYNt42BtG2tb0ate9sA2Fk3n-jKJTvTinFyefKd9P6I7_WnQU_KjSUcdjdd_vwS_1bfxoKVsJEgoBi_vDFL8vsc869Fni8NgyrD2WcOagWCtEk2RtiepTTHnhJuHMsD0Ak_v9D08vcDTTOoCryRe_NnkQ9o9rSJ4fRJgGdXBY9LZeiyEnE9oZ-2i_3-Ny38s7OCDt2b4hkfMu7hPoYDQoDPXTH9eVmjZIGgFKMWZ-A1acch2</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>Millett, Caitlin E</creator><creator>Mukherjee, Dahlia</creator><creator>Reider, Aubrey</creator><creator>Can, Adem</creator><creator>Groer, Maureen</creator><creator>Fuchs, Dietmar</creator><creator>Postolache, Teodor T</creator><creator>Kelleher, Shannon L</creator><creator>Saunders, Erika F.H</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170901</creationdate><title>Peripheral zinc and neopterin concentrations are associated with mood severity in bipolar disorder in a gender-specific manner</title><author>Millett, Caitlin E ; Mukherjee, Dahlia ; Reider, Aubrey ; Can, Adem ; Groer, Maureen ; Fuchs, Dietmar ; Postolache, Teodor T ; Kelleher, Shannon L ; Saunders, Erika F.H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-36581b01cdd07e0a128308de34adabc4e64d19c4cc63b8b5b10fcea7db71273b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Affect - physiology</topic><topic>Biological marker</topic><topic>Biomarkers - blood</topic><topic>Bipolar depression</topic><topic>Bipolar Disorder - blood</topic><topic>Bipolar Disorder - psychology</topic><topic>Female</topic><topic>Gender</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Male</topic><topic>Neopterin - blood</topic><topic>Psychiatry</topic><topic>Severity of Illness Index</topic><topic>Sex Factors</topic><topic>Zinc</topic><topic>Zinc - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Millett, Caitlin E</creatorcontrib><creatorcontrib>Mukherjee, Dahlia</creatorcontrib><creatorcontrib>Reider, Aubrey</creatorcontrib><creatorcontrib>Can, Adem</creatorcontrib><creatorcontrib>Groer, Maureen</creatorcontrib><creatorcontrib>Fuchs, Dietmar</creatorcontrib><creatorcontrib>Postolache, Teodor T</creatorcontrib><creatorcontrib>Kelleher, Shannon L</creatorcontrib><creatorcontrib>Saunders, Erika F.H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Psychiatry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Millett, Caitlin E</au><au>Mukherjee, Dahlia</au><au>Reider, Aubrey</au><au>Can, Adem</au><au>Groer, Maureen</au><au>Fuchs, Dietmar</au><au>Postolache, Teodor T</au><au>Kelleher, Shannon L</au><au>Saunders, Erika F.H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peripheral zinc and neopterin concentrations are associated with mood severity in bipolar disorder in a gender-specific manner</atitle><jtitle>Psychiatry research</jtitle><addtitle>Psychiatry Res</addtitle><date>2017-09-01</date><risdate>2017</risdate><volume>255</volume><spage>52</spage><epage>58</epage><pages>52-58</pages><issn>0165-1781</issn><eissn>1872-7123</eissn><abstract>Abstract Bipolar disorder (BD) is a recurrent, episodic mood disorder for which there are no current diagnostic, prognostic or theranostic biomarkers. Two peripheral markers of the acute phase immune response, zinc and neopterin, are consistently associated with severity of depression in literature. Given gender differences in clinical presentation of BD and in inflammatory processes, we aimed to explore the interaction between gender and immune biomarkers to predict mood severity in BD. Participants with DSM IV BD I and II were recruited through the Pennsylvania Psychiatric Institute during an acute mood episode. Healthy controls (HC) were recruited through advertisements. Participants fasted for at least 6 h when blood was drawn for biomarkers. We found that zinc concentrations were significantly lower in the BD group at baseline (p<.05), and there was also a significant interaction between gender and zinc (p<.05), associated with depression severity. Also, we found a significant interaction between gender and neopterin, associated with mania severity (p<.05). We found that mania severity was associated with neopterin in men, while depression severity was positively associated with zinc in women. Our report bears replication in larger samples and highlights the potential for differences in the underlying pathophysiology between men and women with BD.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>28528241</pmid><doi>10.1016/j.psychres.2017.05.022</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Psychiatry research, 2017-09, Vol.255, p.52-58 |
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| source | ScienceDirect Freedom Collection |
| subjects | Adult Affect - physiology Biological marker Biomarkers - blood Bipolar depression Bipolar Disorder - blood Bipolar Disorder - psychology Female Gender Humans Inflammation Male Neopterin - blood Psychiatry Severity of Illness Index Sex Factors Zinc Zinc - blood |
| title | Peripheral zinc and neopterin concentrations are associated with mood severity in bipolar disorder in a gender-specific manner |
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