A pilot study on commonality and specificity of copy number variants in schizophrenia and bipolar disorder

Schizophrenia (SZ) and bipolar disorder (BD) are known to share genetic risks. In this work, we conducted whole-genome scanning to identify cross-disorder and disorder-specific copy number variants (CNVs) for these two disorders. The Database of Genotypes and Phenotypes (dbGaP) data were used for di...

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Bibliographic Details
Published in:Translational psychiatry 2016-05, Vol.6 (5), p.e824-e824
Main Authors: Chen, J, Calhoun, V D, Perrone-Bizzozero, N I, Pearlson, G D, Sui, J, Du, Y, Liu, J
Format: Article
Language:English
Subjects:
45/43
692/699/476/1333
692/699/476/1799
Adult
Behavioral Sciences
Biological Psychology
Bipolar Disorder - genetics
Bipolar Disorder - psychology
DNA Copy Number Variations - genetics
Female
Genetic Predisposition to Disease - genetics
Genome-Wide Association Study
Genotype
Humans
Male
Medicine
Medicine & Public Health
Neurosciences
Original
original-article
Pharmacotherapy
Phenotype
Pilot Projects
Polymorphism, Single Nucleotide - genetics
Psychiatry
Schizophrenia - genetics
Schizophrenic Psychology
Sensitivity and Specificity
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Summary:Schizophrenia (SZ) and bipolar disorder (BD) are known to share genetic risks. In this work, we conducted whole-genome scanning to identify cross-disorder and disorder-specific copy number variants (CNVs) for these two disorders. The Database of Genotypes and Phenotypes (dbGaP) data were used for discovery, deriving from 2416 SZ patients, 592 BD patients and 2393 controls of European Ancestry, as well as 998 SZ patients, 121 BD patients and 822 controls of African Ancestry. PennCNV and Birdsuite detected high-confidence CNVs that were aggregated into CNV regions (CNVRs) and compared with the database of genomic variants for confirmation. Then, large (size⩾500 kb) and small common CNVRs (size
ISSN:2158-3188
2158-3188
DOI:10.1038/tp.2016.96