Dosimetry for lung tumorigenesis induced by urethane, 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and benzo[a]pyrene (B[a]P) in A/JJmsSlc mice

Some chemicals are known to be lung carcinogens in rodents. While many studies using two-stage models have administered medium or high doses to mice, few have tested lower doses. The dose dependence of urethane, 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and benzo[a]pyrene (B[a]P), t...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Toxicologic Pathology 2017, Vol.30(3), pp.209-216
Main Authors: Onami, Saeko, Okubo, Chigusa, Iwanaga, Asuka, Suzuki, Hiroaki, Iida, Hajime, Motohashi, Yurie, Tomonari, Yuki, Otake, Seiji, Tsuji, Hiroyuki, Yoshimura, Hiroyuki
Format: Article
Language:English
Subjects:
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
Animal models
Benzo(a)pyrene
Carcinogens
Chemicals
Dosimeters
Dosimetry
Ethyl carbamate
Lung cancer
lung tumorigenesis
Lungs
Mice
Original
Pyrene
Rodents
Tumorigenesis
Tumorigenicity
urethane
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Some chemicals are known to be lung carcinogens in rodents. While many studies using two-stage models have administered medium or high doses to mice, few have tested lower doses. The dose dependence of urethane, 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and benzo[a]pyrene (B[a]P), three well-known lung carcinogens at high doses, has not been sufficiently reported in lower dose ranges. Our study evaluated the tumorigenicity of urethane, NNK, and B[a]P at 26 weeks after a single intraperitoneal administration of each compound within medium to low dose in male and/or female A/JJmsSlc (A/J) mice. Dose-dependent tumorigenesis was demonstrated histopathologically for the three compounds. These results suggested that the tumorigenicity of these chemicals is dose dependent in A/J mice, even at lower doses than previously reported.
ISSN:0914-9198
1881-915X
1347-7404
DOI:10.1293/tox.2017-0005