Emerging Targets of Diuretic Therapy

Diuretics are commonly prescribed for treatment in patients with hypertension, edema, or heart failure. Studies on hypertensive and salt‐losing disorders and on urea transporters have contributed to better understanding of mechanisms of renal salt and water reabsorption and their regulation. Protein...

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Bibliographic Details
Published in:Clinical pharmacology and therapeutics 2017-09, Vol.102 (3), p.420-435
Main Authors: Cheng, C‐J, Rodan, AR, Huang, C‐L
Format: Article
Language:English
Subjects:
Animals
Diuretics - adverse effects
Diuretics - pharmacology
Drug Design
Edema - drug therapy
Heart Failure - drug therapy
High-Throughput Screening Assays
Humans
Hypertension - drug therapy
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Summary:Diuretics are commonly prescribed for treatment in patients with hypertension, edema, or heart failure. Studies on hypertensive and salt‐losing disorders and on urea transporters have contributed to better understanding of mechanisms of renal salt and water reabsorption and their regulation. Proteins involved in the regulatory pathways are emerging targets for diuretic and aquaretic therapy. Integrative high‐throughput screening, protein structure analysis, and chemical modification have identified promising agents for preclinical testing in animals. These include WNK‐SPAK inhibitors, ClC‐K channel antagonists, ROMK channel antagonists, and pendrin and urea transporter inhibitors. We discuss the potential advantages and side effects of these potential diuretics.
ISSN:0009-9236
1532-6535
DOI:10.1002/cpt.754