Economic impact of thermostable vaccines

Highlights • Thermostable vaccines can relieve bottlenecks in vaccine supply chains. • The question remains whether benefits would outweigh the additional costs. • Computational modeling quantified economic impact of making vaccines thermostable. • Thermostable formulations were highly cost-effectiv...

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Bibliographic Details
Published in:Vaccine 2017-05, Vol.35 (23), p.3135-3142
Main Authors: Lee, Bruce Y, Wedlock, Patrick T, Haidari, Leila A, Elder, Kate, Potet, Julien, Manring, Rachel, Connor, Diana L, Spiker, Marie L, Bonner, Kimberly, Rangarajan, Arjun, Hunyh, Delphine, Brown, Shawn T
Format: Article
Language:English
Subjects:
Allergy and Immunology
Benin - epidemiology
Charging
Computer Simulation
Cost engineering
Cost reduction
Cost-Benefit Analysis
Economic impact
Economics
Formulations
Health economics
Humans
Immunization
Impact analysis
India - epidemiology
Infant
Logistics
Niger - epidemiology
Rotavirus
Rotavirus Infections - epidemiology
Rotavirus Infections - prevention & control
Rotavirus Vaccines - economics
Rotavirus Vaccines - supply & distribution
Storage
Supply chains
Switching
Temperature
Thermostable vaccines
Vaccine Potency
Vaccines
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Summary:Highlights • Thermostable vaccines can relieve bottlenecks in vaccine supply chains. • The question remains whether benefits would outweigh the additional costs. • Computational modeling quantified economic impact of making vaccines thermostable. • Thermostable formulations were highly cost-effective or cost-effective in most scenarios explored. • Medical costs and productivity savings outweighed significant price premiums.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2017.03.081