A Diagnostic Marker to Discriminate Childhood Apraxia of Speech from Speech Delay: II. Validity Studies of the Pause Marker

Purpose: The purpose of this 2nd article in this supplement is to report validity support findings for the Pause Marker (PM), a proposed single-sign diagnostic marker of childhood apraxia of speech (CAS). Method: PM scores and additional perceptual and acoustic measures were obtained from 296 partic...

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Published in:Journal of speech, language, and hearing research language, and hearing research, 2017-04, Vol.60 (4), p.S1118-S1134
Main Authors: Shriberg, Lawrence D, Strand, Edythe A, Fourakis, Marios, Jakielski, Kathy J, Hall, Sheryl D, Karlsson, Heather B, Mabie, Heather L, McSweeny, Jane L, Tilkens, Christie M, Wilson, David L
Format: Article
Language:English
Subjects:
Adolescent
Age of Onset
Aged
Aged, 80 and over
Apraxia
Apraxias - classification
Apraxias - diagnosis
Apraxias - etiology
Child
Child, Preschool
Children
Clinical Diagnosis
Cohort Studies
Delayed Speech
Diagnosis
Diagnosis, Differential
Female
Humans
Language Development Disorders - classification
Language Development Disorders - diagnosis
Language Tests
Male
Middle Aged
Neurological Impairments
Physiological aspects
Sensitivity and Specificity
Speech Acoustics
Speech Articulation Tests
Speech disorders
Speech Impairments
Supplement: A Diagnostic Marker to Discriminate Childhood Apraxia of Speech From Speech Delay
Young Adult
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Summary:Purpose: The purpose of this 2nd article in this supplement is to report validity support findings for the Pause Marker (PM), a proposed single-sign diagnostic marker of childhood apraxia of speech (CAS). Method: PM scores and additional perceptual and acoustic measures were obtained from 296 participants in cohorts with idiopathic and neurogenetic CAS, adult-onset apraxia of speech and primary progressive apraxia of speech, and idiopathic speech delay. Results: Adjusted for questionable specificity disagreements with a pediatric Mayo Clinic diagnostic standard, the estimated sensitivity and specificity, respectively, of the PM were 86.8% and 100% for the CAS cohort, yielding positive and negative likelihood ratios of 56.45 (95% confidence interval [CI]: [1.15, 2763.31]) and 0.13 (95% CI [0.06, 0.30]). Specificity of the PM for 4 cohorts totaling 205 participants with speech delay was 98.5%. Conclusion: These findings are interpreted as providing support for the PM as a near-conclusive diagnostic marker of CAS.
ISSN:1092-4388
1558-9102
DOI:10.1044/2016_JSLHR-S-15-0297