Gastric Hyperplastic Polyps Associated with Proton Pump Inhibitor Use in a Case without a History of Helicobacter pylori Infection

A 56-year-old man with gastroesophageal reflux disease (GERD) was referred to our hospital. Esophagogastroduodenoscopy (EGD) revealed no evidence of any polypoid lesions in the stomach, and the patient had no history of Helicobacter pylori infection. He received omeprazole (20 mg) once daily for the...

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Bibliographic Details
Published in:Internal Medicine 2017/07/15, Vol.56(14), pp.1825-1829
Main Authors: Miyamoto, Shuichi, Kato, Mototsugu, Matsuda, Kana, Abiko, Satoshi, Tsuda, Momoko, Mizushima, Takeshi, Yamamoto, Keiko, Ono, Shoko, Kudo, Takahiko, Shimizu, Yuichi, Hatanaka, Kanako C., Tsunematsu, Izumi, Sakamoto, Naoya
Format: Article
Language:English
Subjects:
Adenomatous Polyps - diagnostic imaging
Adenomatous Polyps - etiology
Case Report
gastric hyperplastic polyp
gastrin
gastrin receptor
Gastroesophageal reflux
Gastroesophageal Reflux - drug therapy
Helicobacter Infections
Helicobacter pylori
Humans
Infections
Internal medicine
Lesions
Male
Middle Aged
Omeprazole
Omeprazole - adverse effects
Omeprazole - therapeutic use
Polyps
proton pump inhibitor
Proton pump inhibitors
Proton Pump Inhibitors - adverse effects
Protons
Risk factors
Stomach
Stomach Neoplasms - diagnostic imaging
Stomach Neoplasms - etiology
Treatment Outcome
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Summary:A 56-year-old man with gastroesophageal reflux disease (GERD) was referred to our hospital. Esophagogastroduodenoscopy (EGD) revealed no evidence of any polypoid lesions in the stomach, and the patient had no history of Helicobacter pylori infection. He received omeprazole (20 mg) once daily for the GERD. EGD was performed at 1 year after the start of omeprazole administration, and this time, gastric hyperplastic polyps (GHPs) were detected. The GHPs increased in size as the omeprazole treatment continued, but they markedly decreased in size following omeprazole discontinuation. Thus, the administration of proton pump inhibitors may be a risk factor for the development of GHP independent of H. pylori infection.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.56.8040